With the accelerated development of high-speed railway construction, the intersecting relationship between high-speed railway line and urban road located in urban area is becoming increasingly prominent. In the process of road scheme design, it is necessary to deal with the intersecting relationship between the two to ensure the operation and structural safety of high-speed railway. Taking the intersecting project of Fanhua Avenue, Yulan Avenue and Feixi Connecting Line of Hefei-Nanchang High-speed Railway in Hefei as an example, two design schemes of node separated interchange are proposed. Starting from the feasibility analysis of the scheme, combined with the impact on the railway, construction difficulty, landscape effect and engineering cost, the optimal scheme is determined after the comprehensive comparison.