Overpass spans the operating lines. Its erection, maintenance and repair are all affected by the underpass operating lines. How to consider the safety and convenience of detection, monitoring, maintenance and dismantling in the stage of design scheme has become a problem to be considered in the design stage of the overpass scheme. Based on the background of a batch of new overpass in Liaoning Province, the design scheme of overpass is considered from the full life cycle. The problems that need to be solved in each life link and the methods to be realized are fully considered to ensure that the overpass has good performance during the full life cycle, has little impact on the operating railway and has the best economic benefits. Three design schemes are compared and analyzed from the transportation, erection, design details, maintenance and repair, stage cost and life cycle cost, and the other aspects to obtain the different design schemes applicable under the different external conditions, which provides the references for the rapid erection, intelligent maintenance and life cycle costs of overpass railway and highway bridge.