Municipal drainage pipe network is an important urban infrastructure, which is built along with municipal roads at the same time and is a basic project to ensure the normal operation of the city. Municipal drainage pipe network mainly includes rainwater pipe network and sewage pipe network. The design of municipal drainage pipe network should be based on the upper level planning, combined with the actual situation of the site, choose the appropriate drainage system and design parameters, and closely cooperate with other projects in the pipeline layout to achieve the scientific and rational design of drainage pipe network. Combined with the drainage pipe network design case of Xiong'an New Area high-speed railway station, this paper introduces the problems and solutions encountered in the design of this area from the aspects of design parameters, hydraulic calculation, pipeline buried depth, structure layout, professional cooperation and construction sequence, in order to provide reference for related design.