The cold in-place recycling technique has the advantages of convenient construction, small pollution, high recycling rate of old materials, and saving cost. It is utilized in the highway maintenance. Taking S49 Xinyang Expressway as an example, the cold in-place recycling technique is systematically studied from the aspects of applicable conditions, mixture design, pavement performance verification and socioeconomic benefit. The result shows that the application effect of cold in-place recycling technique in the expressway maintenance engineering is ideal and can be popularized and applied.