设计变更方案技术经济评价方法

笔者在文中分析了设计变更方案评价与工程总体设计方案评价之间的关系,提出了设计变更方案评价的6大指标体系,即质量指标、工期指标、财务指标、功能指标、工艺指标和安全指标.并运用价值工程原理建立了设计变更方案的评价模型.     

一种新的胰腺炎脑损伤模型的建立

目的 建立一种稳定的胰腺炎并脑损伤模型,以进一步探讨胰腺炎脑损伤的机制.方法 24只成年雄性SD大鼠,随机分为假手术(sham operation, SO)组,重症急性胰腺炎(SAP)组和胰蛋白酶制模组(trypsin),每组8只大鼠.各组大鼠均于制模后12h采集脑组织和胰腺组织标本.比较各组大鼠的死亡率;采用酶联免疫吸附试验(enzyme linked immunosorbent assay, ELISA)测定血清细胞间紧密连接蛋白(Zo-1)含量;透射电镜观察脑组织超微结构变化;HE染色观察脑组织病理学变化.结果 SAP组大鼠死亡率较trypsin组明显升高,SO组无大鼠死亡;SAP组Zo-1水平均明显高于SO组(P<0.05),trypsin组Zo-1水平与SAP组呈现一致性变化(P>0.05).SAP组和trypsin组均出现明显神经元细胞肿胀、毛细血管淤血、血管通透性增加、血栓形成、线粒体肿胀和细胞凋亡等超微结构的变化.结论 胰蛋白酶可能为SAP脑损伤的元凶;用胰蛋白酶制备SAP模型大鼠死亡率低,为进一步研究脑损伤的机制和进行相关治疗研究提供了稳定的动物模型.     

Method of estimating human error probabilities in construction for structural reliability analysis based on analytic hierarchy process and failure likelihood index method

Partial safety factors must be evaluated precisely for the given target reliability index to ensure the certain level of structural reliability due to uncertain factors. The current studies of partial safety factors do not consider human error in construction for structural reliability. A mathematically model should be improved to simulate the partial safety coefficient concerned uncertainty factors which concern the effect of human error in construction. We employ the contaminated distribution to obtain the realistic mean value and standard variance of variable of structural parameters which coexist with random error human error. The reasonable partial safety coefficient can be calculated based on the realistic value of structural parameters concerned the effects of random error and gross error.     

Network structure and reliability analysis of a new integrated circuit card payment system for hospital

This paper proposes a redundant network communication structure for the patient integrated circuit（IC）card payment system in a hospital information system（HIS）,compares it with the network structure of normal hospital IC card system,and calculates the reliabilities of the related communications like the RS485communication and the Ethernet communication.The new structure can efectively promote the reliability of the hospital operation and ensure the payment collection when the Ethernet network is broken.The system is applied to a local hospital and the cost-performance rate is satisfactory during the application.     

Sensitivity analysis of parameters for multi-stand roll forming using a new booting model

Multi-stand roll forming is a process that has very complicated deformation behaviour and shows significant nonlinearity.In this paper, the sensitivity analysis of parameters for multi-stand roll forming was performed via a new booting finite element method(FEM) model.Compared with the most of simulation, the new model is more consistent with production process and can account for the effects of roll rotating speed.Based on the model, the process of an open section channel formed with 10 passes was simulated and the sensitivity analysis was conducted with orthogonal experiment design combined FEM model.The multi-stand roll forming process can be efficiently analyzed by the new booting model.And sensitivity analysis shows the hardening exponent plays an important role in controlling the quality of the products.     

伴随祖国母亲走向新生

时光荏苒,岁月如梭。 六十年前,我们伟大的祖国在浴火中重生。     

主动免疫联合HCG治疗原因不明性习惯性流产疗效评价

目的　评价主动免疫联合绒毛膜促性腺激素 (HCG)治疗习惯性流产的临床疗效。方法　 2 3 4例原因不明性习惯性流产 (UHA)患者中 92例接受主动免疫 (丈夫淋巴细胞皮内注射 )联合HCG治疗 ,另 84例和 5 8例分别给予单纯主动免疫治疗或单纯HCG治疗。结果　联合治疗组妊娠成功率为 86 .96 % ,对照组妊娠成功率分别为 5 2 .3 3 %和 2 7.5 8% ,差异有显著性。结论　主动免疫联合HCG治疗习惯性流产优于其他方法。     

基于新AHP法的公路路网后评价中环境影响的模糊综合评价

笔者改进了传统的AHP法,构建三标度判断矩阵,采用层次分析法与多层次模糊综合评价法相结合的评价模型来评价公路路网后评价中的环境影响,这样避免了采用九标度方法构建判断矩阵时权重选择的模糊性,从而减少了决策者的主观臆断性.     

可拓综合评判模型在工程风险评价中的应用

根据物元可拓性理论,运用可拓评判方法建立工程风险的综合评判模型,并将其应用于解决多层次的工程风险评价问题,为工程项目风险管理提供了一种有效的分析方法.     

可拓综合评判模型在工程风险评价中的应用

根据物元可拓性理论,运用可拓评判方法建立工程风险的综合评判模型,并将其应用于解决多层次的工程风险评价问题,为工程项目风险管理提供了一种有效的分析方法.     

一种新的鸡胚尿囊膜模型的建立与应用

目的建立一种新的鸡胚尿囊膜模型并考察氢化可的松对鸡胚尿囊膜血管生成的影响。方法运用假气室法建立鸡胚尿囊膜模型,采用硅胶环、甲基纤维素、明胶海绵、玻璃纤维滤纸为给药载体进行考察。结果用硅胶环作为载体建立的鸡胚尿囊膜实验模型,是一种较理想的研究抗血管生成药物的筛选模型。硅胶环作为载体与明胶海绵和纤维滤纸载体等相比,具有效果直观,加样量准确,在显微镜下易于观察、照相的优点。氢化可的松对鸡胚尿囊膜新生血管生成具有较好的抑制作用,呈现出较好的量效关系。结论本研究建立了一种新的鸡胚尿囊膜模型,运用该模型得出氢化可的松对鸡胚尿囊膜血管生成有明显的抑制作用。     

广元城区河段裁弯工程对通航条件的影响

嘉陵江广元城区河段为多个连续弯道组成的复杂河湾,弯道阻力大,行洪能力弱,导致广元城区洪灾频繁,损失十分严重.为了提高广元市城区河段的防洪能力,拟实施嘉陵江塔山湾河段裁弯综合治理工程,但工程对河势和航运的影响较大.本文通过河工模型试验,主要从通航角度对单一裁弯方案、双河并存裁弯方案的布置与整治效果进行了分析比较,双河并存方案老河槽内通航条件较好、对河势的影响相对较小,选择其为推荐实施方案.     

求一类无穷级数和的新方法

基于基础数学知识,建立了求一类无穷级数和的新方法。     

Simplified model for evaluation of VIV-induced fatigue damage of deepwater marine risers

A simplified empirical model for fatigue analysis of deepwater marine risers due to vortex-induced vibration (VIV) in non-uniform current is presented. A simplified modal vibration equation is employed according to the characteristics of deepwater top tensioned risers. The response amplitude of each mode is determined by a balance between the energy feeding into the riser over the lock-in regions and the energy dissipated by the fluid damping over the remainder based on the data from self-excited oscillation and forced oscillation experiments of rigid cylinders. Multi-modal VIV fatigue loading is obtained by the square root of the sum of squares approach.Compared with previous works, this model can take fully account of the main intrinsic natures of VIV for low mass ratio structures on lock-in regions, added mass and nonlinear fluid damping. In addition, a closed form solution of fatigue damage is presented for the case of a riser with uniform mass and cross-section oscillating in a uniform flow. Fatigue analysis of a typical deepwater riser operating in Gulf of Mexico and West Africa shows that the current velocity profiles affect the riser's fatigue life significantly and the most dangerous locations of the riser are also pointed out.     

一种病毒性哮喘模型制作方法的建立及评价

目的评价用呼吸道合胞病毒(RSV)诱导鸡卵白蛋白(OVA)致敏,建立小鼠急性病毒性哮喘模型的方法及效果。方法BALB/c小鼠100只,随机分为磷酸盐缓冲液(PBS/PBS)对照组、PBS/RSV组、RSV/RSV组、OVA/PBS组和OVA/RSV组5组。应用OVA多点注射致敏、OVA气道雾化吸入结合RSV滴鼻激发复制急性病毒性哮喘模型。观察小鼠哮喘急性发作症状;动物体描箱法测定乙酰胆碱(Ach)激发条件下气道反应性(以肺阻力RL表示);支气管肺泡灌洗液(BALF)作细胞分类计数;HE染色观察肺组织病理变化。结果①以45、135、405μg/mL Ach激发时,与其他各组比较,OVA/RSV组RL均显著升高(P均<0.01);②BALF中炎性细胞分类计数,与其他各组比较,OVA/RSV组的细胞总数、淋巴细胞、嗜酸性粒细胞、中性粒细胞均显著升高(P均<0.01);③OVA/RSV组的肺组织病变程度重于其他各组(P均<0.01)。结论RSV诱导OVA致敏的方法建立小鼠急性病毒性哮喘模型是成功的。     

结核多表位DNA疫苗免疫效果及其对小鼠耐药结核病的疗效观察

目的研究比较结核分枝杆菌Hsp70、Ag85A、ESAT-6多表位DNA疫苗和卡介苗(BCG)的免疫效果,观察该疫苗联合抗结核药物治疗耐药结核病小鼠的疗效。方法随机将BALB/c小鼠分成A、B、C组,分别用PBS、BCG和多表位DNA疫苗经皮下免疫,1、3、5周各免疫1次。免疫后眼球采血,分离血清,用酶联免疫吸附试验(ELISA)间接法测定特异性IgG抗体,用ELISA双抗体夹心法测定IL2和IFN-γ;同时分离小鼠脾细胞,用MTT法测定淋巴细胞增殖指数。为观察多表位疫苗的疗效,小鼠尾静脉注射结核分枝杆菌双耐菌株(耐利福平和耐异烟肼),4周后将感染模型小鼠随机分成D、E、F 3组,其中D组为阴性对照,注射生理盐水;E组用利福平、异烟肼治疗;F组为联合用药组,用结核分枝杆菌Hsp70、Ag85A、ESAT-6多表位DNA疫苗和利福平、异烟肼联合治疗,疗程均为10周。治疗结束后称取小鼠体重,取其肺、肝、脾,称取质量,并作肺和脾脏菌落计数。结果多表位DNA疫苗组小鼠血清特异性IgG抗体、IL2、IFN-γ和淋巴细胞增殖指数均明显高于PBS组和BCG组(P<0.05);多表位DNA疫苗联合抗结核化疗药能明显降低耐药结核病小鼠肺、脾菌落计数和肺、肝和脾脏指数(P<0.05)。结论结核分枝杆菌Hsp70、Ag85A、ESAT-6多表位DNA疫苗能在小鼠体内诱导较强的特异性免疫反应,产生高水平的特异性IgG抗体、诱导IL2和IFN-γ分泌和特异性淋巴细胞增殖,并能显著提高抗结核药物对耐药结核病小鼠的疗效。     

边坡稳定分析中极限平衡法与强度折减法比较研究（Ⅱ）

分别用极限平衡法和有限元强度折减法对于高家坪高边坡开挖后防护前的边坡稳定性进行分析,综合两种方法的结果提出高边坡的防护方案;并且对防护后的高边坡,再次用两种方法进行整体稳定性分析。通过比较研究,强度折减法的可行性及优越性得到了充分论证。     

边坡稳定分析中极限平衡法与强度折减法比较研究(Ⅱ)

分别用极限平衡法和有限元强度折减法对于高家坪高边坡开挖后防护前的边坡稳定性进行分析,综合两种方法的结果提出高边坡的防护方案;并且对防护后的高边坡,再次用两种方法进行整体稳定性分析。通过比较研究,强度折减法的可行性及优越性得到了充分论证。