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and Computing Technology,Central South U     

Identity-based Encryption with Non-Interactive Opening

An identity-based encryption(IBE) was studied with non-interactively opening property that the plain text of a ciphertext can be revealed without affecting the security of the encryption system.Two kinds of non-interactive opening properties for IBE schemes were defined along with a concrete scheme in each case.     

Numerical Integration with Derivatives

A new formula with derivatives for numerical integration was presented. Based on this formula and the Richardson extrapolafion process, a numerical integration method was established. It can converge faster than the Romberg＇s. With the same accuracy, the computation of the new numerical integration with derivatives is only half of that of Romberg＇s numerical integration.     

Virtual Reality with Haptic Application

IntroductionThe use of computers to model complicatedsets of data into a sensible form is a concept thatdates back to at least 1 960 .This idea evolved into“scientific visualization”a broad term encompass-ing the use of various techniques for the represen-tation of scientific data in a more easily under-standable format,such as3D plotting.Advancedcomputer graphics,in conjunction with auditoryand haptic feedback channels including tactile dis-play methods,are common tools for achieving suchco…     

Kernel Factor Analysis Algorithm with Varimax

Kernal factor analysis （KFA） with vafimax was proposed by using Mercer kernel function which can map the data in the original space to a high-dimensional feature space, and was compared with the kernel principle component analysis （KPCA）. The results show that the best error rate in handwritten digit recognition by kernel factor analysis with vadmax （4.2%） was superior to KPCA （4.4%）. The KFA with varimax could more accurately image handwritten digit recognition.     

Trusted Anomaly Detection with Context Dependency

Introduction Privilegedprocessesareoftencommonattack targetsbecausetheseprocessesthatprovidesys-temservicesandresourcesexecutewithspecial privileges.Infact,thetracesofsystemcallsexe-cutedbytheprivilegedprocessesaretheordered sequenceinUNIXoperatingsystem.Becausethe tracesofsystemcallsexecutedbythetheseprivi-legedprocessesputupbetterstabilityunderthe conditionofnormaloperationstheyareconsidered asbetterauditdatasourceascomparedwithsys-temaudittrails,systemlogsandapplicationlogs.Consequently,a…     

Monitoring Thermal Coagulation with Ultrasonic Textures

The feasibility of using B-mode ultrasound image textures and pattern recognition technique to characterize the thermal coagulation in vitro during radiofrequency ablation was investigated. The changes of ultrasonic textures in the different regions of samples varied with the heating time in the in-vitro experiments, which would result in that the coagulated and noncoagulated regions of tissue had different ultrasonic textures. Using support vector machine to extract the ultrasonic texture features and characterize the state of tissue, the size and boundaries of thermal lesions could be detected and measured more exactly than only using the gray scale information of B-mode ultrasound image. The proposed method would be applied to the image-guided radiofrequency ablation (IGRA) procedure for monitoring the thermal coagulation.     

A Model of Car-Following with Adaptive Headway

Introduction Reasonably accurate mathematical modeling oftraffic engineering is needed not only for better un-derstanding of the collective behavior of traffic,but also for analyzing flow conditions, designingefficient control strategies, etc[1]. For the past fewdecades, many researches have been done on thissubject and a wide range of traffic flow theoriesand models have been developed. According to thelevel-of-detail with which the traffic flow is de-scribed, these traffic models are classif…     

OFDM System Channel Estimation with Hidden Pilot

Channel estimation using pilot is common used in OFDM system.The pilot is usually time division multiplexed with the informative sequence.One of the main drawbacks is bandwidth losing.In this paper,a new method was proposed to perform channel estimation in OFDM system.The pilot is arithmetically added to the output of OFDM modulator.Receiver uses the hidden pilot to get an accurate estimation of the channel.Then pilot is removed after channel estimation.The Cramer-Rao lower bound for this method was deprived.The performance of the algorithm is then shown.Compared with traditional methods,the proposed algorithm increases the bandwidth efficiency dramatically.     

Tool Wear Prediction in Micro-end-milling with Hard Material

The applications of micro-machining have increased drastically in the last ten years. However, tools with less than 1mm diameter using for micro-mills have very short and unpredictable life when they are used to cut hard metals. In this study, preliminary design of experiment (DOE) test program was conducted to investigate and identify the factors affecting tool wear at the micro-scale with hard material. Analysis of variance (ANOVA) and Taguchi method were efficient to determine appropriate cutting condition and the effect of parameters. A simple model was also developed to predict the width of slots on the workpiece along the cutting length. The obtained results can provide the basic guidelines for parameter setting of micro-end-milling with hard material.     

宫颈癌Ⅱ_b患者术中大剂量放疗前后T细胞亚群水平的变化

目的　探讨术中放疗对宫颈癌Ⅱb 患者细胞免疫功能的影响。方法　在放疗前后,用流式细胞技术检测61 例宫颈癌Ⅱb 患者T淋巴细胞亚群水平(包括CD4、CD8、CD4/CD8)的变化。其中28 例行术中放疗(IROT),33 例行单纯放疗(SR),并与20例正常人作对照。结果　单纯放疗组和术中放疗组在放疗前CD4,CD4/CD8 均明显低于正常组(P<0.001),而前两组间CD4、CD8、CD4/CD8 无显著性差异;放疗后两组CD4、CD4/CD8 较放疗前均下降,CD8 上升,单纯放疗组CD4、CD4/CD8 明显低于术中放疗组(P<0.05)。结论　与单纯放疗相比,宫颈癌术中大剂量放疗对患者免疫系统的影响较轻,有利于机体的恢复。     

自身免疫性甲状腺炎和甲亢原位免疫电镜研究

利用ABC免疫酶技术和一组淋巴细胞亚群、巨噬细胞,HLA-DR抗原的单克隆抗体及免疫电镜技术观察了10例甲状腺炎,7例甲亢伴甲状腺炎,6例甲亢。结果发现甲状腺内有大量活化T淋巴细胞浸润。引人注目地是甲状腺上皮细胞可异常表达DR抗原,且随着淋巴细胞浸润的增多,炎性破坏加重,甲状腺上皮细胞DR抗原的异常表达亦增多。I_2~+、T_8~+、T_4~+细胞、M_5~+细胞和Leu7~+细胞均可与甲状腺滤泡上皮细胞接触并侵入上皮细胞内。免疫活性细胞的直接杀伤作用,可能是甲状腺上皮细胞受损的重要因素。     

Induction of animal model of Graves' disease in BALB/c mice

Objective To construct an animal model of Graves' disease (GD) by immunizing BALB/c mice with hM12 cells co-expressing major histocompatibility complex (MHC) class Ⅱ molecules and human thyrotropin receptor (TSHR) molecules. Methods BALB/c mice in experimental group (H-2d) were immunized with hM12 cells Intraper-itoncally every 2 weeks for six times, while mice in control group were immunized with M12 cells. Five weeks later, the thyroids were histologically examined, and serum samples were tested for thyroid-stimulating antibodies (TSAb) and thyroid hormone levels. Results One BALB/c mouse in experimental group developed Graves'-like disease. Total T4 and T3 levels in this mouse were above the upper limit of normal, TSAb activity was displayed in its serum. The thyroid histologically showed the features of thyroid hyperactivity including thyrocyte hypercellularity and colloid absorption.None of control mice developed Graves'-like disease. Conclusion An animal model with some characteristics of human Graves' disease was successfully induced and the model will facilitate studies aimed directly at understanding the patho-genesis of autoimmunity in Graves' disease.     

单纯性肥胖儿童免疫功能的研究

使用流式细胞仪（ＦＣＭ）对１２名单纯性肥胖症儿童及２０名正常儿童进行了９项淋巴细胞亚群检测对比，结果发现肥胖症儿童ＣＤ３＋细胞、ＣＤ４＋细胞及ＣＤ４＋／ＣＤ８＋之比明显降低（Ｐ＜０．０１）；ＣＤ１９＋细胞、ＣＤ５６＋细胞、ＨＬＡ－ＤＲ＋细胞均出现有意义的升高；ＣＤ８＋细胞、ＣＤ２５＋细胞、ＣＤ５７＋细胞虽较正常儿童有所升高，但经统计学处理无明显差异。检测结果表明：单纯性肥胖儿童的免疫功能有较明显紊乱。提示肥胖症儿童的脂肪酸摄取过剩对免疫功能有一定损害。     

Graves’病样自然杀伤T细胞缺如小鼠血清TSH受体抗体的水平

目的　探讨自然杀伤T细胞 (naturalkillerTcell,NKT)在Graves’病发病中的作用。方法　用表达有人TSH受体的细胞免疫NKT细胞缺如小鼠和野生型BLAB/c小鼠 ,每两周一次 ,共 6次。在最后一次免疫结束后两周处死小鼠 ,检测血清甲状腺素水平 ,TSH受体抗体。结果　免疫后的NKT细胞缺如小鼠 ,血清TT4和TRAb水平轻度升高 ,并且与对照组比较 ,有显著性差异。但是 ,在经免疫的NKT细胞缺如小鼠和野生型小鼠之间 ,血清平均TT4水平和TRAb水平相似 ,且TSAb与TSBAb水平变化两组之间无显著性差异。结论　NKT细胞可能不参与Graves’病的发生     

IMMUNOHISTOCHEMICAL STUDY OF ESTROGEN AND PROGESTERONE RECEPTOR IN THYROID TISSUES OF AUTOIMMUNE THYROID DISEASE

ＳｈｉＢｉｎｇｙｉｎ（施秉银）；ＺｈａｎｇＸｕｃｈｉｎ（张学斌）；ＧａｏＨｕｉ（高慧）；ＭａＸｉｕｐｉｎｇ（马秀萍）；ＷａｎｇＭｉｎ（王敏）ＩＭＭＵＮＯＨＩＳＴＯＣＨＥＭＩＣＡＬＳＴＵＤＹＯＦＥＳＴＲＯＧＥＮＡＮＤＰＲＯＧＥＳＴＥＲＯＮＥＲＥＣＥＰＴ...     

乙型肝炎病毒对T细胞亚群的侵犯及对其功能的影响

以单克隆抗体补作溶解法分离T4、T8细胞亚群，PCR检测65例各型乙肝患者T细胞亚群和PBMCs中的HBVDNA，结合细胞免疫功能改变探讨HBV侵犯免疫细胞对其功能的影响。结果表明：PBMCs中HBVDNA阳性24例（24／65，36．92％），不同类型乙肝患者阳性率差异较大；T4、T8、细胞亚群中HBVDNA阳性分别为16例和21例，HBVDNA阳性组IL2R表达明显降低，抑制细胞功能有不同程度的下降；提示HBV对T8细胞可能更具亲嗜性，HBV对免疫细胞的侵犯是乙肝患者细胞免疫功能紊乱的原因之一。     

Foxp3在自身免疫性甲状腺病患者外周血和病变组织中的表达

目的检测自身免疫性甲状腺病(AITD)患者Foxp3的表达,探讨调节性T细胞(Treg)与AITD发病的关系。方法采用Real-time PCR检测AITD患者及健康对照者外周血及甲状腺组织中Foxp3mRNA的表达;免疫组织化学方法检测甲状腺内Foxp3蛋白的表达;Western blot方法检测外周血单个核细胞Foxp3蛋白的表达。结果与对照组相比,AITD患者外周血单核细胞Foxp3mRNA表达显著降低(P<0.05);桥本甲状腺炎(HT)患者外周血单个核细胞Foxp3蛋白表达下降(P<0.05),Graves病(GD)患者外周血单个核细胞Foxp3蛋白表达与对照组相比无差异(P>0.05)。与对照组相比,HT患者甲状腺组织Foxp3mRNA和蛋白表达均升高(P<0.05),而GD患者甲状腺组织Foxp3mRNA和蛋白表达水平与对照组相比无显著性差异(P>0.05)。结论 CD4+CD25+Foxp3+Tregs的减少和/或功能的减退可能是诱导AITD尤其是HT发生的因素。     

THE CLINICAL SIGNIFICANCE OF TSAb IN GRAVES' DISEASE

ＧａｏＨｕｔ（高慧）；ＪｉｎＳｈｉｘｉｎ（金世鑫）；ＺｏｎｇＪｉａｎｑｉ（宗建奇）；ＬｉＪｉａｎ（李健）；ＭａＸｉｕｐｉｎｇ（马秀萍）；ＳｈｉＢｉｎｇｙｉｎ（施秉银）ＴＨＥＣＬＩＮＩＣＡＬＳＩＧＮＩＦＩＣＡＮＣＥＯＦＴＳＡｂＩＮＧＲＡＶＥＳ＇ＤＩＳＥ...     

恶性淋巴瘤T细胞亚群及白介素2活性的观察

应用免疫碱性磷酸酶桥联（ＡＰＡＡＰ）法及３Ｈ－ＴＤＲ掺入法检测了３０例非何杰金淋巴瘤（ＮＨＬ）外周血Ｔ淋巴细胞亚群及１４例ＮＨＬ患者白介素２（ＩＬ－２）活性。结果表明：ＮＨＬ患者外周血全Ｔ细胞、ＯＫＴ４细胞的均显著减少（Ｐ＜０．０５），ＯＫＴ８细胞显著增多（Ｐ＜０．０５），ＯＫＴ４／ＯＫＴ８比值明显低于对照（Ｐ＜０．０１），ＩＬ－２活性明显低于对照（Ｐ＜０．０１），ＩＬ－２活性与ＯＫＴ４／ＯＫＴ８比值呈正相关。