REGULATION OF PRODUCTION OF PARATHYROID HORMONE－RELATED PEPTIDE （PTHrP） AND EXPRESSION OF ITS mRNA IN A HUMANLIVER－DERIVED CE

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Information needs of the continuing urban transportation planning process

Urban transportation is identified as a functional element in the broader context of urban facilities and services. From this point of view, the relative merits of separate information systems for transportation planning and general urban planning, as contrasted to unified systems for all urban management functions, are discussed. The overriding need to make the most effective use of urban resources argues strongly for the unification of urban information systems to the greatest possible extent consistent with the special data requirements of various functional programs. The need to identify and correlate data items for very small areal units and to keep current records of the constantly shifting patterns of social and economic activities in urban areas present difficult, but not insurmountable technical problems. However, the most serious barrier to the development and implementation of comprehensive urban information systems is concluded to be institutional, rather than technical, in nature.     

An application of variance reduction techniques in freeway simulation

Computer simulation models are used in a variety of applications in transportation engineering and have become a prime aid in decision making. The applications range from evaluating traffic control strategies for single intersections to such complex decision processes as evaluating the impact of removing toll facilities at the George Washington Bridge in New York City. While it is widely accepted that simulation offers an unmatchable capability of evaluating alternate control policies, the high variance of the output variable presents a critical problem in such comparative analyses. The simulation models with high output variance must be run longer or replicated many times to achieve a desired precision level, and that corresponds to increased cost of computer resources. This paper describes and illustrates the application of variance reduction concepts that can improve the reliability and efficiency of the simulation experimental process by taking advantage of the simulation model structure. The two variance reduction concepts (common random numbers and antithetic variates) reduce the variance of the output variable by replacing the original sampling procedure with a new procedure that yields the same expected value but with a smaller variance. The application of the variance reduction concept was illustrated using results from experiments with a freeway simulation model. The results indicate that both common random numbers and antithetic variates sampling procedures appreciably reduce the variance of the simulation output measure.     

Seabed scene simulation and its realization in extending Vega

Realistic simulation of underwater scene is always difficult because of the special and complex vision effects in underwater space. Seabed is an important part of underwater environment. This paper describes the methods for seabed scene simulation based on OpenGL. It includes construction of fluetuant terrain based on the random sinusoidal algorithm, simulation of seabed flicker effect by means of circular texture mapping and generation of turbidity effect by using fog techniques. For the application based on the leading high level 3D development environment-Vega, underwater scene simulation is still a difficulty since there is no module for it. Based on the analysis of Vega software and the research on seabed scene simulation methods, a Vega extending module named “Underwater Space” was created through developing module class and extending lynx interface. The module class was designed through developing DLL written in C . The Lynx was extended through developing keyword configure file, GUI configure file and lynx plug-in DLL. The problem that Vega can‘t simulate underwater space, is elementarily resolved. The results show that this module is efficient, easy using, and the seabed scene images am vivid.     

Roll Dynamics of Commercial Vehicles

An analytical model is developed here for studying the roll dynamics of commercial vehicles. Large displacements and rotations are accounted for in this nonlinear model so that it can be used for the study of roll dynamics well beyond the limits of wheel lift-off. The model is used to illustrate some of the dynamic phenomena in vehicle rollover, especially the interactive coupling between the roll and the vertical modes of motion. The influence of suspension backlash on rollover resistance is demonstrated, and the phenomenon of roll motion resonance is illustrated to suggest new means for evaluating vehicle rollover sensitivity.     

Comment Some reflections on port competition in the United States and western Europe

'Port competition' is a rather puzzling expression. This paper approaches it literally, searching for precise meanings. In seaports that contain complex and changeable mixtures of public and private enterprise, who competes and why? The answers to these questions are not conclusive but suggestive indications are found in the US, UK and northwestern Europe. Finally, we discuss what seem to be the key influential factors which may impact on the competitiveness of a port.     

A bi‐level programming approach — Optimal transit fare under line capacity constraints

The fare of a transit line is one of the important decision variables for transit network design. It has been advocated as an efficient means of coordinating the transit passenger flows and of alleviating congestion in the transit network. This paper shows how transit fare can be optimized so as to balance the passenger flow on the transit network and to reduce the overload delays of passengers at transit stops. A bi‐level programming method is developed to optimize the transit fare under line capacity constraints. The upper‐level problem seeks to minimize the total network travel time, while the lower‐level problem is a stochastic user equilibrium transit assignment model with line capacity constraints. A heuristic solution algorithm based on sensitivity analysis is proposed. Numerical example is used to illustrate the application of the proposed model and solution algorithm.