硒对大骨节病病区人体红细胞免疫功能的影响

目的　探讨硒及含硒的谷胱甘肽过氧化物酶 (GPX)对大骨节病 (KBD)病区人体红细胞免疫功能的影响。方法　测定KBD病区人体血硒含量 ,GPX活性 ,红细胞C36R花环率和IC花环率及血清RCIA促进率和抑制率 ,以及补硒对上述指标的影响。结果　①病区人体血硒含量、GPX活性和红细胞G3bR花环率明显低于非病区 ;血清RCIA抑制率明显高于非病区 ;②病区人体IC花环率 ,血清RCIA促进率与非病区人体无明显差异 ;③补硒 1 2周后 ,血硒含量 ,GPX活性 ,C3bR花环率明显提高 ;血清RCIA抑制率明显降低。④病区人体普遍处于低硒状态 ,且红细胞免疫功能均低下。结论　KBD病区人体红细胞免疫功能低下和血清RCIA抑制因子增高是低硒所致的一种普遍效应 ,而不是KBD病区人体所特有。     

THE STUDIES OF SERUM CVB-SPECIFIC IgM ANTIBODY AND NITRIC OXIDE AMONG THE PATIENTS WITH LATENT AND CHRONIC KESHAN DISEASE

Keshan disease is an endemic myocardiopathycharacterised by the degeneration and necrosis ofmyocardiac tissue. The etiology and pathogenesisof Keshan disease are still unknown. Many studieshave proved that enterovirus,for example coxsack-ievirus B(CVB)might play an important role in theetiopathology of Keshan disease[l.2J.Nitric Oxide (NO)is a small molecule gas withmultiple biological actions known to be importantin a variety of physiology and pathological process-es. NO is known to play…