Graves’病样自然杀伤T细胞缺如小鼠血清TSH受体抗体的水平

目的　探讨自然杀伤T细胞 (naturalkillerTcell,NKT)在Graves’病发病中的作用。方法　用表达有人TSH受体的细胞免疫NKT细胞缺如小鼠和野生型BLAB/c小鼠 ,每两周一次 ,共 6次。在最后一次免疫结束后两周处死小鼠 ,检测血清甲状腺素水平 ,TSH受体抗体。结果　免疫后的NKT细胞缺如小鼠 ,血清TT4和TRAb水平轻度升高 ,并且与对照组比较 ,有显著性差异。但是 ,在经免疫的NKT细胞缺如小鼠和野生型小鼠之间 ,血清平均TT4水平和TRAb水平相似 ,且TSAb与TSBAb水平变化两组之间无显著性差异。结论　NKT细胞可能不参与Graves’病的发生     

Electron spin resonance analyse on the production of hydroxyl radicals by ozone photolysis

AbstractIn order to explore the production of hydroxyl radical(·OH)in a confined space,a novel ozone-light irradiation system is constructed in this study,and the·OH radical is measured by spin-trapping electron spin resonance(ESR)method in which 5,5-dimethyl-1-pyrroline-N-oxide(DMPO)is selected as the spin-trap.Several influence factors including the light intensity,the irradiation time and DMPO mass concentration are discussed. The results show that in this experimental system,with DMPO mass concentration of 1g/L and the irradiation time of 30 min,the·OH radical can be best captured.Besides,both wavelength and intensity of the irradiation light could effect the generation of·OH radical.These results are of great importance to further study the sterilization effect of·OH radical in confined space.     

THE EFFECT OF FCγ RECEPTOR ON THE PATHOGENESIS OF GRAVES'''' DISEASE

Graves diseaseisanorganspecificautoimmunediseasewhichismainlycausedbyhumoralresponse .Anti TSHreceptorantibodyisoneofthemostim portantfactorsthatcausethe physiopathologicchangeofthiskindofdisease .RecentstudiesofvariousFcreceptorgeneknockoutmice (FcRKOmice)haveprovidedstrongevidencethatFcrecep tors (FcR) playedcrucialrolesinmanyautoimmunediseases ,suchasauto antibody dependentexperi mentalhemolyticanemiaandthrombocy topenia[1- 3] .Inthepresentstudy ,wetriedtoex ploretheroleofFcγreceptoro…