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建成的各类桥梁由于设计缺陷、施工控制、运营车辆长期严重超载等原因,加之桥梁的技术状态得不到及时有效地监测,以及受洪水冲刷、车船撞击等外因作用,使得为数众多的桥梁发生了各种不同程度的病害,如桥面破损、栏杆断裂、梁板裂缝、钢筋钢索锈蚀、钢结构裂纹锈烂、墩台断裂位移等,破坏了桥梁的正常功能状态。本文介绍旧桥碳纤维板加固技术对高速公路养护中危桥原有功能进行恢复,以提高旧桥的承载能力。 相似文献
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Fungal infection remains a major problem worldwide, yet treatment options are limited owing to the lack of effective drugs, the significant toxicity of available compounds, and the emergence of drug resistance. The low toxicity of calcofluor white (CFW) is an attractive antifungal compound for its known inhibitive effects on trichophyton rubrum and candida albicans growth. However, the efficacy of CFW is limited in most cases. In order to search for effective means to improve its efficacy, using saccharomyces cerevisiae as a model, we have used microarrays to examine the cell's response when treated with CFW on the genome scale. We found that both the PKC-SLT2 (i.e, protein kinase C-mitogen activated protein kinase) and the glycogen metabolic pathways are activated upon CFW treatment. These results suggest that the key components in these pathways could be targeted by other drugs to counter the cell's compensative response, thus to further substantiate the inhibitive effect of CFW on fungal growth, which may lead to treatment regimens with improved efficacy of this compound in clinical applications. 相似文献
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李晓林 《国防交通工程与技术》2018,(2)
作为一种新型的边坡支护方式,预应力锚索抗滑桩在加固边坡工程中得到了广泛的应用。以某边坡治理工程为依托,利用ABAQUS有限元分析软件进行数值模拟,分别对桩位置、桩长、桩截面尺寸、锚固段长度、预应力大小等参数对预应力锚索抗滑桩加固边坡的稳定性影响状况进行了分析,确定了边坡治理工程应采用的最佳加固方案。结果表明加固后在暴雨工况下,边坡处于稳定状态,设计优化方案合理可行。 相似文献
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