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肺癌患者外周血T细胞亚群及免疫细胞活性的研究
引用本文:董西林!第二临床医学院呼吸内科,西安,王雅娟!第二临床医学院呼吸内科,西安,孙秀珍!第二临床医学院呼吸内科,西安,景芬茸!第二临床医学院呼吸内科,西安,李家芝!第二临床医学院呼吸内科,西安.肺癌患者外周血T细胞亚群及免疫细胞活性的研究[J].西安交通大学学报(医学版),1999(4).
作者姓名:董西林!第二临床医学院呼吸内科  西安  王雅娟!第二临床医学院呼吸内科  西安  孙秀珍!第二临床医学院呼吸内科  西安  景芬茸!第二临床医学院呼吸内科  西安  李家芝!第二临床医学院呼吸内科  西安
作者单位:Department of Internal Medicine,Second Affiliated Hospital
摘    要:采用 APAAP法和流式细胞仪研究 32例肺癌患者及 30例健康人外周血T细胞亚群及免疫细胞活性 ( NK- A)的变化。结果表明 :肺癌患者外周血 CD+3 、CD+4、CD+4/CD+8及 NK- A与正常人比较呈显著性降低 ( P <0 .0 5 ,P <0 .0 1 ) ;且肺癌伴癌转移者与未转移者上述各项指标亦有显著性差异 ( P <0 .0 5 )。说明肺癌患者存在细胞免疫功能降低 ;伴有癌转移的肺癌患者细胞免疫功能更低。提出积极调节肺癌患者细胞免疫功能 ,增强机体抗肿瘤能力十分重要。

关 键 词:肺肿瘤  T细胞亚群  免疫细胞  天然杀伤细胞  APAAP桥联酶标法

STUDY OF T-CELL SUBJECTS AND NK-A IN PERIPHERAL BLOOD OF PATIENTS WITH LUNG CANCER
Dong Xilin,Wang Yajuan,Sun Xiuzhen et al.STUDY OF T-CELL SUBJECTS AND NK-A IN PERIPHERAL BLOOD OF PATIENTS WITH LUNG CANCER[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(4).
Authors:Dong Xilin  Wang Yajuan  Sun Xiuzhen
Abstract:T cell subjects and NK A in peripheral blood were measured by APAAP and Flow Cytometry in 32 patients with lung cancer.The results showed that the proportion of CD - 3,CD + 4 ratio of CD + 4/CD + 8 and NK A decreased significantly (P<0.05 or P<0.01) in comparison with normal control group.In addition, the proportion of CD + 3,CD + 4 ratio of CD + 4/CD + 8 and NK A in lung cancer with metastasis was significantly lower than that of lung cancer with nometastasis (P<0.05).It suggests that the cell immunie function in patients with lung cancer is decreased obviously.So it is important to improve the cell immunie function of patients with lung cancer.
Keywords:lung tumor  T  cell subjects  immunocyte  NK  A  APAAP
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