| 醋酸棉酚对雄性大鼠血清中睾酮、LH 水平、激素活性及其受体的作用 |
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| 引用本文： | 李凤源,王廼功,雷海鹏.醋酸棉酚对雄性大鼠血清中睾酮、LH 水平、激素活性及其受体的作用[J].西安交通大学学报(医学版),1987(2). |
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| 作者姓名： | 李凤源 王廼功 雷海鹏 |
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| 作者单位： | 西安医科大学药理学教研室，中国医学科学院药物研究所，中国医学科学院药物研究所 |
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| 摘 要： | 本文研究了醋酸棉酚对雄性大鼠血清中睾酮、LH 水平、激素活性及其受体的作用,取得了肯定的结果。实验在236只成龄雄鼠体进行,用棉酚灌胃,母天20～40mg/kg,分别持续8～42天。结果表明,血清中黄体生成素和睾丸酮水平不受影响;但在去势鼠,棉酚可降低血清中黄体生成素的水平;当施棉酚每天按20mg/kg,持续8天时,前列腺和精囊的重量不受影响,当增加棉酚为每天40mg/kg,持续10天时,上述性器官重量降低;棉酚不影响前列腺上雄激素受体量。实验提示前列腺和精囊湿重下降,是非特异性对抗作用所致。而雄性激素活性下降可能与性功能低下有关。
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EFFECT OF GOSSYPOL ON TESTOSTERONE AND LH IN SERUM ANDROGEN ACTIVITY AND ANDROGEN RECEPTOR IN RATS |
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| Li Fengyuan.EFFECT OF GOSSYPOL ON TESTOSTERONE AND LH IN SERUM ANDROGEN ACTIVITY AND ANDROGEN RECEPTOR IN RATS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1987(2). |
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| Authors: | Li Fengyuan |
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| Institution: | Department of Pharmacology |
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| Abstract: | The experiment was made on 236 adu- lt male rats.The rats were given Gossypol on 20-40 mg/kg/d for 8-42 days.The results showed no effect on testosterone and LH level in serum.However,it decreased LH level when rats were castrated.When Go- ssypol was given on 20 mg/kg/d for 8 days,no effect on the weight of prostate gland and vcsicula seminalis was observed. When Gossypol was increased to 40 mg/kg /d for 10 days,the weight of the organs was decreased.Gossypol showed no effect on Androgen Recept in prostate. |
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| Keywords: | gossypol testosterone LH androgens prostate |
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