| The expressions and significance of MMP-2 and TIMP-2 in human pancreatic carcinoma |
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| 作者姓名： | 董博 马清涌 李明 |
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| 作者单位： | [1]Department of General Surgery, Shaanxi＇ Provincial People＇s Hospital, Taiyuan 030012, China [2]Department of Hepatobiliary Surgery, the First Affiliated Hospital, Medical School of Xi＇an Jiaotong University, Xi＇an 710061, China [3]Department of Histology and Embryology, Medical School of Xi＇an Jiaotong University, Xi＇an 710061, China |
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| 摘 要： | Objective To study the expressions of MMP-2 and TIMP-2 in pancreatic carcinoma and their relationship with tumor invasion, local metastasis and prognosis of the carcinoma. Methods The expressions of MMP-2 and TIMP-2 were examined in 32 patients with pancreatic carcinomas by S-P immunohistochemical technique and the correlation with pathological tumor parameters were analyzed. Survival analysis was made by using the Kaplan-Meier method. Results The positive rates of MMP-2, TIMP-2 in 32 patients with pancreatic carcinoma were 56.25% and 75.00%, which were significantly higher than those of the controls（P〈0.05）. Expressions of MMP-2 and TIMP-2 were independent of sex, age, histological grading and type, but well correlated with the lymph node metastasis and TNM clinical staging （Ⅰ and Ⅲ, Ⅱ and Ⅲ ）. There was a significant association between MMP-2, TIMP-2 and prognosis in pancreatic carcinoma. Conclusion MMP-2 and TIMP-2 might be useful markers for biological aggressiveness of this malignancy and might contribute to the invasive properties of pancreatic carcinoma, which can be used to evaluate the prognosis of patients.
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| 关 键 词： | 胰腺癌 MMP-2 TIMP-2 基因表达 诊断 临床意义 |
| 文章编号： | 1671-8267（2007）01-0107-03 |
The expressions and significance of MMP-2 and TIMP-2 in human pancreatic carcinoma |
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| Dong Bo,Ma Qingyong,Li Ming.The expressions and significance of MMP-2 and TIMP-2 in human pancreatic carcinoma[J].Academic Journal of Xi’an Jiaotong University,2007,19(1):107-109,F0003. |
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| Authors: | Dong Bo Ma Qingyong Li Ming |
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| Abstract: | Objective To study the expressions of MMP-2 and TIMP-2 in pancreatic carcinoma and their relationship with tumor invasion, local metastasis and prognosis of the carcinoma. Methods The expressions of MMP-2 and TIMP-2 were examined in 32 patients with pancreatic carcinomas by S-P immunohistochemical technique and the correlation with pathological tumor parameters were analyzed. Survival analysis was made by using the Kaplan-Meier method. Results The positive rates of MMP-2, TIMP-2 in 32 patients with pancreatic carcinoma were 56.25% and 75.00%, which were significantly higher than those of the controls(P＜0.05). Expressions of MMP-2 and TIMP-2 were independent of sex, age, histological grading and type, but well correlated with the lymph node metastasis and TNM clinical staging(Ⅰ and Ⅲ, Ⅱ and Ⅲ). There was a significant association between MMP-2, TIMP-2 and prognosis in pancreatic carcinoma. Conclusion MMP-2 and TIMP-2 might be useful markers for biological aggressiveness of this malignancy and might contribute to the invasive properties of pancreatic carcinoma, which can be used to evaluate the prognosis of patients. |
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| Keywords: | pancreatic carcinoma MMP-2 TIMP-2 prognosis |
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