| 肺癌TNF-α的表达及其意义 |
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| 引用本文： | 贾彦民,陈明伟,马建光.肺癌TNF-α的表达及其意义[J].西安交通大学学报(医学版),2000,21(5):428-230. |
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| 作者姓名： | 贾彦民 陈明伟 马建光 |
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| 作者单位： | 西安交通大学第一医院呼吸科，西安 710061 |
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| 摘 要： | 目的 探讨TNF-α基因在肺癌组织中的表达及其临床意义。方法 应用免疫组化SP法检测40例肺癌组织中肿瘤坏死因子(Tumor necrosis factor,TNF-α)的表达，并与癌旁正常肺组织对照。结果 TNF-α阳性表达主要分布于癌细胞胞浆中，阳性率为47..5%(19/40)，细胞核内无阳性表达；癌旁正常肺组织内无阳性表达(P＜0..05)。结论 TNF-α与肺癌的发生、发展有着密切关系。
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| 关 键 词： | 肺肿瘤 肿瘤坏死因子 免疫组织化学 |
| 文章编号： | 0258-0659(2000)05-0425-03 |
| 修稿时间： | 2000年5月19日 |
The expression of in the tissue of primary bronchogenic carcinoma and its sig nificance nificance//Jia Yanmin, Chen Mingwei, Ma Jianguang |
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| Jia Yanmin,CHEN Mingwei,Ma Jianguang.The expression of in the tissue of primary bronchogenic carcinoma and its sig nificance nificance//Jia Yanmin, Chen Mingwei, Ma Jianguang[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2000,21(5):428-230. |
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| Authors: | Jia Yanmin CHEN Mingwei Ma Jianguang |
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| Abstract: | Objective To détect in the tissue of primary bronchogenic carcinoma(PBC) and discuss its significance. Methods was assessed by immunohistochemical method ot SP in paraffin tissue sections of 40 PBC and paratumor normal lung tissue. Results The positive rate of TNF-a in cytoplasm of carcinoma cells was 47.5 % (19/40), and it was not found in all paratumor normal lung tissue(P< 0.05). Conclusion TNF-a gene expressed in some patients with broncho genic carcinoma. The growth of bronchogenic carcinoma is related to TNF-a gene. |
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| Keywords: | lung neoplasm tumor necrosis factor immunohistochemistry |
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