| 心肌炎患者T淋巴细胞亚群改变 |
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| 引用本文： | 张王刚,王香玲,齐惠滨,王兰君.心肌炎患者T淋巴细胞亚群改变[J].西安交通大学学报(医学版),1992(1). |
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| 作者姓名： | 张王刚 王香玲 齐惠滨 王兰君 |
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| 作者单位： | 西安医科大学第二附属医院内科学教研室，西安医科大学第二附属医院内科学教研室，西安医科大学第二附属医院内科学教研室，西安医科大学第二附属医院内科学教研室 西安 710061，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文应用淋巴细胞单克隆抗体检测了两型心肌炎患者外周血淋巴细胞亚群,发现心肌炎心力衰竭组患者的T_8亚群明显低于心肌炎心律失常组及正常人,而T_4/T_8比值明显升高。同时用短寿命细胞法发现心肌炎心力衰竭组患者的抑制性T淋巴细胞功能明显降低,并与射血分数之间存在明显的正相关。免疫调节异常在心力衰竭型心肌炎的发病中起重要作用。
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| 关 键 词： | 心肌炎 心力衰竭 单克隆抗体 淋巴细胞亚群 抑制性T淋巴细胞功能 |
STUDY OF LYMPHOCYTE SUBSETS AND FUNCTION OF THE SUPPRESSIVE T LYMPHOCYTE IN PATIENTS WITH VIRAL MYOCARDITIS |
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| Zhang Wanggang,Wang Xiangling,Qi Huibin,et al.STUDY OF LYMPHOCYTE SUBSETS AND FUNCTION OF THE SUPPRESSIVE T LYMPHOCYTE IN PATIENTS WITH VIRAL MYOCARDITIS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(1). |
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| Authors: | Zhang Wanggang Wang Xiangling Qi Huibin |
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| Abstract: | The frequency of peripheral lymphocyte subsets using monoclonal was studied in patients with viral myocarditis (MC). The percentage of T_8 positive cells was significantly lower in patients with MC of heart failure(MCHF) than that in patients with MC of arrhythmias and that in normal controls, whereas the T_4/T_8 ratio was significantly inereased in MCHF patients. At the same time, suppressive T cells (Ts) function in patients with MC was evaluated by shortlived assay. The Ts function was significantly reduced in MCHF patients, close correlation was found between the Ts function and the hemodynamic function in MCHF patients. Abnormal immunoreguiation may be of the important pathogenic factor in MCHF patients. |
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| Keywords: | myocarditis heart failure monoclonal antibodies lymphocyte subsets suppressive T lymphocyte function |
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