肝疏冲剂对脂肪肝模型大鼠的影响

目的观察肝疏冲剂对不同脂肪肝模型大鼠的影响。方法用乙醇和四氯化碳诱发的急性脂肪肝、乙醇和高脂饲料诱发的慢性脂肪肝、乙硫氨酸诱发的急性脂肪肝模型,观察不同剂量的肝疏冲剂对血脂代谢、肝内脂代谢、肝组织病理改变的影响。结果肝疏冲剂使乙醇和四氯化碳性脂肪肝大鼠血清胆固醇(TC)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和碱性磷酸酶(ALP)显著降低,肝内总脂肪和肝糖原(Gn)含量显著降低。可使乙醇和高脂饲料性脂肪肝TC、TG、ALP、LDL和ALT水平显著降低,肝内总脂肪、TG和Gn含量显著降低。肝疏冲剂可使乙硫氨酸性脂肪肝大鼠血清TC、TG和ALT显著降低,高密度脂蛋白(HDL)显著升高,肝内总脂肪、TG和肝糖原含量明显降低。病理切片镜下各用药组大鼠脂肪变性和肝细胞坏死程度均有不同程度的减轻。结论肝疏冲剂可有效地预防和治疗脂肪肝。

The effect of Ganshu Granule on rat model of fatty liver

Objective To observe the effect of Ganshu Granule on different models of fatty liver in rats. Methods Rats with acute fatty liver induced by alcohol and carbon tetrachloride, rats with chronic fatty liver induced by alcohol and high-fat diet, and rats with acute fatty liver induced by ethionine were used, and the effects of different doses of Ganshu Granule on serum lipid metabolism, intrahepatic lipid metabolism and histopathological changes in liver were observed. Results In fatty liver rats induced by alcohol and carbon tetrachloride, Ganshu Granule could reduce the level of total cholesterol (TC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in serum and could decrease total fat and glycogen(Gn) in liver obviously. In fatty liver rats induced by alcohol and high-fat diet, Ganshu Granule could significantly decrease the level of TC, TG, ALP, LDL and ALT in serum and could reduce the content of total fat, TG and Gn in liver obviously. In fatty liver rats induced by ethionine, Ganshu Granule could decrease the level of TC, TG and ALT in serum, raise the level of HDL in serum and could decrease the content of total fat, TG and Gn in liver obviously. The histopathologic results showed the degree of hepatic steatosis and hepatocellular necrosis were lessened in all of the treated groups. Conclusion Ganshu Granule is effective in preventing and treating fatty liver.