| 青藤碱镇痛和抗炎作用机理的研究 |
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| 引用本文： | 霍海如,车锡平.青藤碱镇痛和抗炎作用机理的研究[J].西安交通大学学报(医学版),1989(4). |
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| 作者姓名： | 霍海如 车锡平 |
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| 作者单位： | 西安医科大学药学系药理学教研室，西安医科大学药学系药理学教研室 |
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| 摘 要： | 应用3种镇痛实验方法,青藤碱(Sin)皆呈现镇痛作用:小鼠热板法镇痛实验证明,Sin 口服和皮下注射的 ED_(50)分别为154.9mg/kg 和125.2mg/kg Sin 可抑制小鼠腹腔注射醋酸扭体反应,其 ED_(50)为36.4mg/kg;电刺激小鼠尾部法测痛实验表明,Sin 皮下注射的 ED_(50)为161.2±28.7mg/kg。Sin 腹腔注射可抑制由角叉菜诱发的大鼠足肿胀,并显著降低大鼠足跖炎症渗出物中的 PGE 含量。提示 Sin抑制炎症局部 PG 的合成和/或释放的作用可能是其镇痛和抗炎作用机理之一。Sin对小鼠静脉注射的 LD_(50)为156.7(144.9～169.4)mg/kg。
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| 关 键 词： | 青藤碱 镇痛实验 角叉菜炎症 前列腺素 |
STUDY ON MECHANISM OF SINOMENINE(SIN)OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES |
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| Huo Hairu Che Xiping.STUDY ON MECHANISM OF SINOMENINE(SIN)OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1989(4). |
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| Authors: | Huo Hairu Che Xiping |
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| Abstract: | In three analgesic experiments,Sin showed analgesic activity.In the experiment of mice hot plate ethod,the ED_(50) Values of po and sc Sin were 154.9mg/kg and 125.2 mg/kg,respectively.Sin po showedthe inhibitory effect on mouse writhing caused by i.pHAc with the ED_(50) value of 36.4 mg/kg.The ED_(50)valueof sc Sin was 161.2±28.7 mg/kg on the electricalstimulation of mouse tail.Sin i.p markedly inhibited theedema of rat hind paw induced by injecting carrageenininto the plant surface of the hind foot,and reduced thecontents of PGE released from inflammtory tissueof rat hind paw induced by carragecnin.The resultsindicate that the analgesic and anti-inflammatoryactivities of Sin are presumably due to inhibitingsynthesis and or release of prostaglandins. |
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| Keywords: | Sinomenine Analgesic experiment Carrageenin inflammation Prostaglandin |
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