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| 雷诺嗪对兔心房肌细胞快钠电流的影响及使用依赖性阻滞作用 | |
| 引用本文： | 王现青,张嘉莹,严干新,张存泰,高传玉,崔长琮.雷诺嗪对兔心房肌细胞快钠电流的影响及使用依赖性阻滞作用[J].西安交通大学学报(医学版),2010,31(1). |
| 作者姓名： | 王现青 张嘉莹 严干新 张存泰 高传玉 崔长琮 |
| 作者单位： | 1. 华中科技大学同济医学院心内科,湖北武汉,430030;河南省人民医院心内科,河南郑州,450003 2. 河南省人民医院心内科,河南郑州,450003 3. Main Line Health heart Center,Penneylvania,USA 19096 4. 华中科技大学同济医学院心内科,湖北武汉,430030 5. 西安交通大学医学院第一附属医院心内科,陕西西安,710061 |
| 摘 要： | 目的 研究雷诺嗪对兔心房肌细胞快钠电流的影响及其是否存在使用依赖性阻滞作用.方法 应用全细胞膜片嵌记录方法,了解雷诺嗪对兔单个心房肌细胞快钠电流的作用,及在不同刺激频率(1Hz、3.3Hz、5Hz)时对快钠电流的影响.结果 30μmmol/L雷诺嗪对兔心房肌细胞快钠电流有明显的抑制作用,其IC_(50)为(25.6±1.8)μmmol/L,并且随着刺激频率的增加其作用加强,存在使用依赖性.结论 雷诺嗪对兔心房肌细胞快钠电流有一定的抑制作用,其存在使用依赖性阻滞作用. |
| 关 键 词： | 雷诺嗪 快钠电流 使用依赖性 晚钠电流 |
Effect of ranolazine on the fast sodium channel current in rabbit atrial myocytes and use-dependent blockade |
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| WANG Xian-qing,ZHANG Jia-ying,YAN Gan-xin,ZHANG Cun-tai,GAO Chuan-yu,CUI Chang-cun.Effect of ranolazine on the fast sodium channel current in rabbit atrial myocytes and use-dependent blockade[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(1). | |
| Authors: | WANG Xian-qing ZHANG Jia-ying YAN Gan-xin ZHANG Cun-tai GAO Chuan-yu CUI Chang-cun |
| Institution: | WANG Xian-qing1,2,ZHANG Jia-ying2,YAN Gan-xin3,ZHANG Cun-tai1,GAO Chuan-yu2,CUI Chang-cun4(1.Department of Cardiology,Tongji Hospital,Tongji Medical College of HuazhongScience & Technology University,Wuhan 430030,2.Department of Cardiology,Henan Provincial People\'s Hospital,Zhengzhou 450003,China,3.Main Line Health Heart Center,Penneylvania,USA 19096,4.Department of Cardiology,the First Affiliated Hospital,Medical School of Xi\'an Jiaotong University,Xi\'an 710061,China) |
| Abstract: | Objective To explore the effect of ranolazine on the fast sodium channel current (INa) in rabbit atrial myocytes and the existence of use-dependent blockade. Methods Standard whole cell patch clamp technique was used to study the effect of ranolazine on the fast sodium channel current and the use-dependent blockade caused with different frequencies (1Hz, 3.3Hz and 5Hz) to stimulate the cells. Results The 30μmol/L ranolazine significantly reduced INa with an IC_(50) value of (25.6±1.8)μmmol/L and produced a frequency-dependent inhibitory effect on INa with obvious use-dependence. Conclusion Ranolazine can inhibit the fast sodium channel current in rabbit atrial myocytes and indeed has a use-dependent effect. |
| Keywords: | ranolazine fast sodium channel current (INa) use-dependence late sodium current |
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