反复呼吸道感染小儿的体液免疫状态

<正> 小儿由于呼吸系统发育尚不健全,防卫机能未臻完善,呼吸道感染发病率极高。反复呼吸道感染在临床上十分多见,但尚缺乏满意的治疗。造成反复呼吸道感染的原因很多。随着临床免疫学的进展,反复呼吸道感染作为免疫缺陷病的特征已逐渐为人们所重视。关于反复呼吸道感染与机体免疫状态的关系,文献中曾有一些报导,但结果并不完全一致。为此我们测定了60例临床上反复呼吸道感染病史的小儿血清IgG和IgA值,并同时检测41例年龄分布相仿的正常儿者作对照。现将初步结果报告于后。

Humoral Immunological State in Children with Recurrent Respiratory Infections

60 cases with a history of recurrent respiratory infections were studied The serum levels of immunoglobulin G and A were measured by means of radial diffusion and the results were compared with 41 normal subjectsof the same age. In 23 cases (38. 3%), serum IgA level was below meanvalue-SD. It was remarkably decreased in 8 patients with prolonged pneu-monia(P≤0.05). The serum IgG concentration was elevated above mean va-lue + SD in 14 patients, 8 of whom suffered from bronchitis. There was,furthermore, another group of 7 patients with bronchitis whose IgA levelwas elevated above mean value + SD. The results suggested that deficiencyof serum IgA might be a cause of recurrent respiratory infections andmight give rise to a prolonged course of pneumonia in some patients.