| THE ULTRASTRUCTURAL OBSERVATION OF TARGET CELLS ATTACKED BY HUMAN LAK |
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| 作者姓名： | 刘军 陈明霞 陈恒复 杨少毅 张京田 |
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| 作者单位： | Department of Electron Microscope，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | In1982,Grimmetalfirstrepor=edthatanti-tumorlymph0kine-activatedkillercells(LAK)c0uldbegeneratedfromperipheralbloodmononuclearcells(PBMC)activatedbyinterleukin-2(IL-2)`l).Duet0theirhighertumor-kil1ingef-fect,LAKhavebeenusedinad0ptiveim-munotherapyforcancerpatientsandtheclinicalresultsarerathersatisfact0ry',,.ButthekillingmechanismofLAKisnotveryclearyet.Zychlinskyetal0bservedthem0rphol0gyoftargetcellsattackedbymurineLAKandfoundtargetcellsdiedvia.necrosi5andnpnpt0si5simultaneously"'.XuZhe…
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THE ULTRASTRUCTURAL OBSERVATION OF TARGET CELLS ATTACKED BY HUMAN LAK |
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| Liu Jun,Chen Mingxia, Chen Hengfu,Yang Shaoyi,Zhang Jingtian.THE ULTRASTRUCTURAL OBSERVATION OF TARGET CELLS ATTACKED BY HUMAN LAK[J].Academic Journal of Xi’an Jiaotong University,1997(1). |
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| Authors: | Liu Jun Chen Mingxia Chen Hengfu Yang Shaoyi Zhang Jingtian |
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| Abstract: | In order to explore the killing mechanism of LAK, we observed the morphological change of K562 and Raji attacked by human LAK with transmission electron microscope, The result showed that 1 hour after coculture of LAK and target cell, target cell was significantly damaged.Part of target cells died via necrosis, and part via apoptosis. Our findings show that human LAK can kill target cells via necrosis and apoptosis simultaneously |
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| Keywords: | interleukin-2 lymphokine-activated killer cells necrosis apoptosis |
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