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| THE OVEREXPRESSION AND SIGNIFICANCE OF CYCLIN D1 AND P53 IN CERVICAL SQUAMOUS CELL CARCINOMAS | |
| 作者姓名： | 王晓丽 王梅 李明众 宋天保 任娟 尚菊战 |
| 作者单位： | Wang Xiaoli，Wang Mei，Li Mingzhong，Song Tianbao Ren Juan，Shang JuzhanDepartment of Oncology，First Hospital of Xian Jiaotong University，Xian 710061，China. **"Department of Dermatology，Second Hospital of Xi 'an Jiaotong University ***"Department of |
| 摘 要： | Ｄｅｒｅｇｕｌａｔｉｏｎｏｆｃｅｌｌｃｙｃｌｅｃｏｎｔｒｏｌｉｓｎｏｗｃｏｎｓｉｄｅｒｅｄａｋｅｙｅｖｅｎｔｉｎｏｎｃｏｇｅｎｅｓｉｓａｎｄａｌｔｅｒａｔｉｏｎｓｏｆｇｅｎｅｓｉｎｖｏｌｖｅｄｉｎｔｈｉｓｃｏｎｔｒｏｌａｒｅｆｒｅｑｕｅｎｔｆｉｎｄｉｎｇｓｉｎｄｉｆｆｅｒｅｎｔｃａｎｃｅｒｍｏｄｅｌｓ.ＣｙｃｌｉｎＤ1ｈａｓｄｒａｗｎａｔｔｅｎｔｉｏｎａｓａ ｐｏｔｅｎｔｉａｌｏｎｃｏｇｅｎｅｉｎｓｅｖｅｒａｌｃａｎｃｅｒｔｙｐｅｓ .ＣｙｃｌｉｎＤ1ｐａｒｔｉｃｉｐａｔｅｓｉｎｔｈｅｃｏｎｔｒｏｌｏ… |
THE OVEREXPRESSION AND SIGNIFICANCE OF CYCLIN D1 AND P53 IN CERVICAL SQUAMOUS CELL CARCINOMAS |
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| Wang Xiaoli,Wang Mei,Li Mingzhong,Song Tianbao Ren Juan,Shang Juzhan.THE OVEREXPRESSION AND SIGNIFICANCE OF CYCLIN D1 AND P53 IN CERVICAL SQUAMOUS CELL CARCINOMAS[J].Academic Journal of Xi’an Jiaotong University,2002,14(1). | |
| Authors: | Wang Xiaoli Wang Mei Li Mingzhong Song Tianbao Ren Juan Shang Juzhan |
| Institution: | 1. Department of Oncology, First Hospital of Xian Jiaotong University,Xian 710061, China. 2. Department of Dermatology, Second Hospital of Xi 'an Jiaotong University 3. Department of Histology and Embryology, Medical School of Xi 'an Jiaotong Un iversity |
| Abstract: | Objective To investigate the significance of ov erexpresson of cyclin D1 and P53 protein in cervical squamous cell carcinomas.Methods Fifty cases of in vasive cervical squamous cell carcinomas and 10 cases of normal cervical squamou s epithelia were investigated with immunihistochemical technique. Results The overexpression of cyclin D1 and P53 in invasive cer vical carcinomas was 70% and 50 %, respectively. There was no overexpression of them in the control group. The o verexpression of cyclin D1 in grade Ⅱ and Ⅲ was much higher than that in grad eⅠ(P<0.05). The overexpresson of cyclin D1 in stage Ⅲ of cervical carcinom a was significantly higher than that in stage Ⅱ (P＜0.05). The overexpress ion of P53 in grade Ⅱ and grade Ⅲ of cervical carcinoma was remarkably higher than that in grade Ⅰ (P＜0.05).Conclusion The action point of both cyclin D1 and P53 may be at G1/S transition. The overexpression of them was associated with development and progression of cervical carcinoma probably in different mechanisms and differen t pathways. |
| Keywords: | cervical squamous cell carcinoma immunohistochemistry cyclin D1 protein P53 protein |
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