| β-IRRADIATION WITH A LIQUID~(188)Re-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT |
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| 引用本文： | 朱建国,崔长琮,崔翰斌,胡国英,马爱群,王东琦,付文.β-IRRADIATION WITH A LIQUID~(188)Re-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT[J].西安交通大学学报(英文版),2002,14(1). |
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| 作者姓名： | 朱建国 崔长琮 崔翰斌 胡国英 马爱群 王东琦 付文 |
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| 作者单位： | Zhu Jianguo，Cui Changcong，Cui Hanbin，Hu Guoying，Ma Aiqun Wang Dongqi，Fu Wen Department of Cardiology，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China. |
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| 基金项目： | ThisworkissupportedbytheActionProjectofJiaotongUniversity |
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| 摘 要： | Ｐｅｒｃｕｔａｎｅｏｕｓｔｒａｎｓｌｕｍｉｎａｌｃｏｒｏｎａｒｙａｎｇｉｏｐｌａｓｔｙ(ＰＴＣＡ )ｉｓｏｎｅｏｆｔｈｅｍｏｓｔｃｕｒｒｅｎｔｔｈｅｒａｐｉｅｓｆｏｒｃｏｒｏｎａｒｙａｒｔｅｒｙｄｉｓｅａｓｅ ,ｂｕｔｉｔｒｅｍａｉｎｓｌｉｍｉｔｅｄｂｙａ30 %ｔｏ 6 0 %ｒｅｓｔｅｎｏｓｉｓｒａｔｅ .Ｉｎｔｒａｖａｓｃｕｌａｒｂｒａｃｈｙｔｈｅｒａｐｙ (ＩＶＢ)ｉｓａｎｅｆｆｅｃｔｉｖｅｍｅｔｈｏｄｔｏｉｎｈｉｂｉｔｃｏｒｏｎａｒｙｒｅｓｔｅｎｏｓｉｓａｆｔｅｒＰＴＣＡ .Ａｎｅｗｃｏｎｃｅｐｔｏｆｐｒｅ…
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β-IRRADIATION WITH A LIQUID 188Re-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT |
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| Zhu Jianguo,Cui Changcong,Cui Hanbin,Hu Guoying,Ma Aiqun Wang Dongqi,Fu Wen.β-IRRADIATION WITH A LIQUID 188Re-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT[J].Academic Journal of Xi’an Jiaotong University,2002,14(1). |
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| Authors: | Zhu Jianguo Cui Changcong Cui Hanbin Hu Guoying Ma Aiqun Wang Dongqi Fu Wen |
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| Institution: | Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710 061, China. |
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| Abstract: | Objective To evaluate the role of β-irradiatio n with a liquid 188Re-filled balloon for limiting neointimal prolifer ation. Methods Balloon-overstretched injury was performed in the rabb it carotid artery, then β-irradiation using the liquid 188Re-filled balloon was followed immediately, and the prescribed doses was 0, 15Gy or 20Gy a t 0.5mm from the surface of vessel. All animals survived and were sacrificed at three weeks. Histopathologic analysis was performed. Results In the control group, the neointimal area was larger ( 0.40±0.04)mm2, as compared with (0.23±0.06)mm2 of the 15Gy irradiated g roup and (0.15±0.02)mm2 in the 20Gy group (P＜0.05). Conclusion The β-irradiation with a liquid 188Re-f illed balloon is safe and effective. |
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| Keywords: | brachytherapy radiotherapy restenosis prevention |
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