| 阿霉素逆行运输致三叉神经节变化的实验研究 |
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| 引用本文： | 裴秋梅,胡永升,宋彤,张引成.阿霉素逆行运输致三叉神经节变化的实验研究[J].西安交通大学学报(医学版),1994(1). |
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| 作者姓名： | 裴秋梅 胡永升 宋彤 张引成 |
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| 作者单位： | Department of Oral-Maxillofacial surgery，Affiliated Stomatological Hospital |
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| 摘 要： | 将０．５％阿霉素注射到大白鼠一侧眶下神经干内，药物经轴浆逆行传递很快被运输到相应的三叉神经节细胞，术后于同侧三叉神经节观察到阿霉素自体荧光，组织病理学、超微结构及电生理检查发现同侧节细胞有明显的变性和坏死。故认为阿霉素患支神经干内注射治疗原发性三叉神经痛是一种简便、安全、疗效可靠的新治疗方法。
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| 关 键 词： | 三叉神经 逆行轴浆运输 阿霉素 |
TRIGEMINAL SENSORY GANGLIONECTOMY BY RETROGRADE AXONAL TRANSPORT OF ADRIAMYCIN |
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| Pei Qiumei, Hu Yongsheng, Song Tong, et al.TRIGEMINAL SENSORY GANGLIONECTOMY BY RETROGRADE AXONAL TRANSPORT OF ADRIAMYCIN[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1994(1). |
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| Authors: | Pei Qiumei Hu Yongsheng Song Tong |
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| Abstract: | The study describes that 0.5% Adriamycin was injected into the inflaorbital branch of trigeminal nerve in rats and the drug was swiftly transported by retrograde axoplasmic flow into the sensory neuron's counterpart. As a result, Adriamycin specific autofluorescence was seen in trigeminal ganglion. Degeneration and necrosis of the cells were shown under light and electronic microscope,and the trigeminal brainstem evoked potentials became unobtainable. The authors believe that the technique is an uncomplicated, safe and reliable method for dealing with trigeminal neuralgia. |
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| Keywords: | trigeminal nerve retrograde axoplasmic transport adriamycin |
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