| 多抗乙素可增强特异性细胞毒T细胞活性──在体动物实验 |
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| 引用本文： | 王一理,刘华,司履生,薛超,方亮.多抗乙素可增强特异性细胞毒T细胞活性──在体动物实验[J].西安交通大学学报(医学版),1994(2). |
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| 作者姓名： | 王一理 刘华 司履生 薛超 方亮 |
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| 作者单位： | 西安免疫病理学研究室 |
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| 摘 要： | 利用Ｃ５７ＢＬ／６纯系小鼠，皮下接种Ｓ１８０肉瘤细胞建立肿瘤模型，并用多抗乙素进行治疗，结果显示，治疗组肿瘤体积明显小于对照组（０．６６ｃｍ３／１．４８ｃｍ３Ｐ＜０．０５）。以脾细胞为效应细胞，Ｓ１８０肉瘤细胞为靶细胞，检测细胞毒活性，发现治疗组有较高的特异性细胞毒活性（１８０，３１１溶解单位／１３８溶解单位Ｐ＜０．０１）。结合以往的体内外实验结果，推测多抗乙素能够增强特异性细胞毒性Ｔ细胞活性。
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| 关 键 词： | 多抗乙素 生物反应调节剂（BRM） 特异性细胞毒性T细胞（SCTL） |
THE DUOKANGYISU CAN ENHANCE THE SPECIFIC ANTITUMOR ACTIVITY IN MICE IN VIVO |
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| Wang Yili, Liu Hua, Si Lusheng, et al.THE DUOKANGYISU CAN ENHANCE THE SPECIFIC ANTITUMOR ACTIVITY IN MICE IN VIVO[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1994(2). |
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| Authors: | Wang Yili Liu Hua Si Lusheng |
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| Institution: | Institute of Immunopathology |
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| Abstract: | Using C57 BL/6 mice bearing S180 sarcoma as tumor model,the tumor- bearing mice were treated with Duokangyisu,a polysacchride biological response modifier(BRM)isolated from a- streptococcus culture, The results showed that tumor size of treated group was smaller than that of control(0.66cm3/1.84cm3)and cytotoxicity of spleen cells from treated group to autologous tumor cells was higher than that of control also (180,311/138 Lytic units P<0.01).According to our previous data, it is assumed that Duokangyisu has the capacity of enhancing the specific cytotoxic T cell activity in mice. |
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| Keywords: | duokangyisu BRM SCTL |
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