| 克山病病区低硒儿童血小板GSH_(px)和SOD活性以及cAMP含量 |
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| 引用本文： | 杨起凤,徐光禄,翟连榜,薛文岚,吴晶,王立新.克山病病区低硒儿童血小板GSH_(px)和SOD活性以及cAMP含量[J].西安交通大学学报(医学版),1992(4). |
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| 作者姓名： | 杨起凤 徐光禄 翟连榜 薛文岚 吴晶 王立新 |
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| 作者单位： | 西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室，西安医科大学克山病研究室 西安 710061，西安 710061，西安 710061，西安 710061，西安 710061，西安 710061 |
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| 摘 要： | 本文对比测定了克山病病区与非病区儿童血小板GSH_(px)、SOD活性和cAMP水平,以及全血、红细胞、血浆和头发硒含量。结果表明,病区儿童血和发硒均明显低于非病区;血小板GSH_(px)活性比非病区儿童显著低下,但血小板SOD活性和cAMP水平无显著差异。提示病区低硒儿童血小板GSH_(px)活性的降低可能导致血小板功能和代谢的改变。
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| 关 键 词： | 硒 克山病 超氧物歧化酶 谷胱甘肽过氧化物酶 血小板 环腺苷酸 |
PLATELET GSH_(px),SOD ACTIVITIES AND cAMP CONTENTS OF CHILDREN FROM LOW-SELENIUM KESHAN DISEASE AREAS |
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| Yang Qifeng,Xu Guanglu,Zhai Lianbang,et al.PLATELET GSH_(px),SOD ACTIVITIES AND cAMP CONTENTS OF CHILDREN FROM LOW-SELENIUM KESHAN DISEASE AREAS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1992(4). |
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| Authors: | Yang Qifeng Xu Guanglu Zhai Lianbang |
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| Institution: | Research Laboratory of Keshan Disease |
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| Abstract: | In the present study, platelet GSH_(px), SOD activities and cAMP contents, as well as whole blood, erythrocyte, plasma and hair selenium levels were comparatively measured in children from Keshan disease endemic and non-endemic areas. The results showed that blood and hair selenium contents were significantly lower in children of the endemic area than in those of the non-endemic area; children in the endemic area had a signifi cantly lower platelet GSH_(px) activities as compared to those in the non-endemic area, but no remarkable difference of platelet SOD activities and cAMP contents between children in the two areas was observed. The results indicate that the reduced GSH_(px) activity of low-selenium children in the endemic area may result in alterations in platelet functions and arachidonic acid metabolism. |
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| Keywords: | selenium Keshan disease superoxide dismutase glutathione peroxidase platelet cyclic adenosine monophosphate |
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