| 大鼠脑内血肿部分抽吸对红细胞SOD活性的影响 |
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| 引用本文： | 何堪生,刘军,王新成,来华安.大鼠脑内血肿部分抽吸对红细胞SOD活性的影响[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 何堪生 刘军 王新成 来华安 |
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| 作者单位： | 陕西临床医学院 |
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| 基金项目： | 陕西省卫生厅医学重点科技项目 |
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| 摘 要： | 为探讨脑内血肿部分抽吸对血肿触发自由基反应的影响，利用立体定向技术制作脑内血肿大鼠模型并模拟血肿抽吸，观察各组红细胞超氧化物歧化酶（ＳＯＤ）活性的变化。结果显示血肿部分抽吸显著降低红细胞ＳＯＤ活性（Ｐ＜０．０５），提示血肿部分抽吸抑制大鼠体内的自由基反应，其机制可能与减轻血肿周围组织和毛细血管的损伤有关。
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| 关 键 词： | 脑内血肿 血肿抽吸 SOD |
THE EFFECT OF PARTIALLY HEMATOMA EVACUATION ON THE ACTIVITY OF SUPEROXIDE DISMUTASE (SOD) IN ERYTHROCYTE OF MICE WITHINTRACEREBRAL HEMATOMA |
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| He Kansheng,Liu Jun,Wang Xincheng et al.THE EFFECT OF PARTIALLY HEMATOMA EVACUATION ON THE ACTIVITY OF SUPEROXIDE DISMUTASE (SOD) IN ERYTHROCYTE OF MICE WITHINTRACEREBRAL HEMATOMA[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | He Kansheng Liu Jun Wang Xincheng |
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| Abstract: | To detect the effect of partialy hematoma evacuation on the activity of superoxide dismutase SOD in erythrocyte of mice with intracerebral hematoma,a mice modle of intracerebral hematoma was made with anticogulated autologous blood and the partialy hematoma evacuation was imitated by stereotaxy.The activity of SOD in erythrocyte was measured in three groups.The activity of SOD was significantly decreased (P<0.05) in the group in which the hematoma were partialy evacuated.The reaction of free radical was inhibited in mice of intracerebral hematoma by the partialy hematoma evacuation.The possible rationale may be related to the reduction of peribematoma tissues and capillares damage. |
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| Keywords: | intracerebral hematoma hematoma evacuation superoxide dismutase |
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