| 用RP-HPLC法分析地尔硫在兔体内的药动学及组织分布 |
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| 引用本文： | 杨广德,贺浪冲,冯强,王晓旭.用RP-HPLC法分析地尔硫在兔体内的药动学及组织分布[J].西安交通大学学报(医学版),1999(2). |
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| 作者姓名： | 杨广德 贺浪冲 冯强 王晓旭 |
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| 作者单位： | 宁夏石嘴山第二职工医院药剂科 |
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| 摘 要： | 以尼群地平为内标，用反相高效液相色谱法（ＲＰ－ＨＰＬＣ）测定兔口服地尔硫后血浆和组织器官的药物浓度。药动学符合二房室模型。主要参数∶Ｔ１／２（α）＝０．５１ｈ，Ｔ１／２（β）＝６．１１ｈ，Ｔ１／２（ｋａ）＝０．２５ｈ，Ｔ（ｐ）＝０．５２ｈ，口服２ｈ后在胆汁、血、脾、心、肾、肝、大脑和小脑药物浓度分别为∶０．５５９ｍｇ／Ｌ、０．３７５ｍｇ／Ｌ、４．５６２μｇ／ｇ、０．７７１μｇ／ｇ、１．０９３μｇ／ｇ、１．４３９μｇ／ｇ、０．３５９μｇ／ｇ和０．７４１μｇ／ｇ。
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| 关 键 词： | RP－HPLC 地尔硫 药动学 组织分布 |
PHARMACOKINETICS AND TISSUE DISTRIBUTIONOF DILTIAZEM IN RABBITS BY RPHPLC |
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| Yang Guangde,He Langchong,Feng Qiang et al.PHARMACOKINETICS AND TISSUE DISTRIBUTIONOF DILTIAZEM IN RABBITS BY RPHPLC[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1999(2). |
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| Authors: | Yang Guangde He Langchong Feng Qiang |
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| Abstract: | It was reported that a high performance liquid chromatography for the determination of diltiazem in rabbit plasma and tissues in which nitrendipine was used as an internal standard.The concentrationtime curve in rabbits was found to accord with 2compartment model.The main pharmacokinetic parameters were:T1/2()=051h,T1/2()=6.11h,T1/2(ka)=0.52h.The tissue concentration of choeolith,plasma,spleen, heart,kidney ,cerebrum and cerebellum were 0559mg/L,0375mg/L,4562g/g,0771g/g,1093g/g,1439g/g,0359g/g and 0.741 g/g,respectively. |
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| Keywords: | RPHPLC diltiazem pharmacokinetic tissue distribution |
| 本文献已被 CNKI 等数据库收录！ |
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