| 沙棘总黄酮对离体血管平滑肌的作用 |
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| 引用本文： | 于晓江,刘传镐,李孝光,臧伟进,张社团.沙棘总黄酮对离体血管平滑肌的作用[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 于晓江 刘传镐 李孝光 臧伟进 张社团 |
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| 作者单位： | 西安医科大学电生理学研究室
(于晓江，刘传镐，李孝光，臧伟进)，西安医科大学电生理学研究室(张社团) |
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| 摘 要： | 沙棘总黄酮可明显对抗KCl、CaCl_2和去甲肾上腺素对离体血管平滑肌的收缩反应,使量效曲线右移,最大反应压低PD_2′值分别是5.79、5.75和5.81。TFH还可明显抑制家兔主动脉条Ca~(2+)内流依赖性收缩。以上结果表明:TFH的血管扩张作用可能与阻滞钙通道有关。
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| 关 键 词： | 沙棘总黄酮 钙通道阻滞剂 主动脉条 |
EFFECT OF TOTAL FLAVONES OF HIPPOPHASE RHAMNOIDES ON ISOLATED VASCULAR SMOOTH MUSCLES |
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| Yu Xiaojiang,Liu Chuangao,Li Xiaoguang et al.EFFECT OF TOTAL FLAVONES OF HIPPOPHASE RHAMNOIDES ON ISOLATED VASCULAR SMOOTH MUSCLES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Yu Xiaojiang Liu Chuangao Li Xiaoguang |
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| Institution: | Research Laboratory of Electrophysiology |
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| Abstract: | Total flavones of hippophase rhamnoides (TFH) inhibited the contraction of isolated rabbit aortic preparations induced by KCl, CaCl_2 and noradrenaline (NE), shifted the dose-response curvesto the right and depressed the maximal response. PD_2' values were 5.79, 5.75 and 5.81 respectively. TFH could also reduce Ca~(2+) -dependent contraction in rabbit aortic preparations. These results suggest that relaxation of vascular smooth muscles caused by TFH may be due to TFH natagonistic effect on transmembrane Ca~(2+) channels. |
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| Keywords: | total flavoncs of hippophase rhamnoides calcium channel blocker aortic preparations |
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