经尿道切除综合征的实验研究

本文通过经尿道切除综合征(TURS)的实验研究发现:①冲洗液吸收完时,血钠下降最为明显,而它的恢复与血浆甘露醇的消除在时相上并不一致。低钠的影响大且持续的时间长。②冲洗液吸收后,血钾逐渐升高。高钾血症是实验动物死亡的主要原因之一。③等渗的甘露醇冲洗液吸收,血浆渗透压不发生改变。④死亡兔肺重量明显增加,呈肺水肿表现。无脑水肿存在。④根据动物实验推算,经尿道前列腺切除的患者,术中短时间內吸收38ml/kg以上的冲洗液,有发生TURS的可能。上述结果对TURS病理生理改变的认识及其防治提供了实验依据。

EXPERIMENTAL STUDY OF TRANSURETHRAL RESECTION SYNDROME

The experimental study of transurethral resection syndrome (TURS) was made. The results are as follows 1. Maximum depression of plasma sodium occurred at the termination of infusion. The recovery of plasma sodium and the displacement of plasma mannitol were not consistent at the same time. Hyponatraemia gave great influence and lasted for alonger time. 2. Plasma potassium increased gradully after absorbed, which was one of the main reasons inducing the death of the animal. 3. No change occurred in plasma osmolality. 4. The lung weight of died rabbits inereased evidently, showing pulmonary edema. Encephaledemo could not be found. 5. We inferred that if more than 38 ml/kg the irrigating fluid was absorbed during transurethral resection of the prostate, the complication, TURS, could occur. The result mentioned above gave a rdiable basis for us to know and to protect and treat the the syndrome pathophysiologically.