人宫颈癌细胞凋亡与Bcl-2表达的研究 |
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引用本文: | 西安医科大学学报.人宫颈癌细胞凋亡与Bcl-2表达的研究[J].西安交通大学学报(医学版),2000,21(2):162-163. |
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作者姓名: | 西安医科大学学报 |
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作者单位: | 西安医科大学第一附属医院妇产科!西安710061 |
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摘 要: | 目的 探明 Bcl- 2在宫颈癌细胞凋亡过程中的作用。方法 采用 60 Co和顺铂处理体外培养的 3株人宫颈癌细胞株 Hela、Si Ha、RJC,2 4 h后检测细胞凋亡和 Bcl- 2。结果 发现放射线 60Co和顺铂均可以诱发宫颈癌细胞凋亡 ;它们都表达 Bcl- 2 ,其表达率随着细胞凋亡的出现而下降 ;两种因素联合应用后诱导细胞凋亡和降低 Bcl- 2表达的作用增强。结论 Bcl- 2的表达可能参与了宫颈癌细胞凋亡的调节过程
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关 键 词: | 细胞凋亡 Bcl-2 宫颈癌细胞 |
Studies
on apoptosis and the expression of Bcl-2 in human cervical carcinoma cells |
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Abstract: | Objective In order to study the function of Bcl 2 in the process of apoptosis in cervical carcinoma cells.Methods 60 Co and cisplatin (CDDP) were used to treat 3 cultured human cervical cancer cell lines Hela, SiHa and RJC.The characteristic apoptotic changes and the expression of Bcl 2 were obsevred after 24 hours.Results Both 60 Co and cisplatin could induce apoptosis respectively.The expression of Bcl 2 was detected in all the cell lines and was decrased with apoptotic cell death.The function of initiating apoptosis and decreasing Bcl 2 expression was enhanced when 60 Co and cisplatin were applied in combination.Cnclusion These indicate that Bcl 2 is involved in regulation of apoptosis in human cervical carcinoma cells. |
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Keywords: | apoptosis Bcl 2 cervical carcinoma cells |
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