| 脂质过氧化对培养人胚肝细胞的损伤作用 |
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| 引用本文： | 和水祥,任瑛云,韩瑽,舒昌杰,谢蔚玫,贺美丽.脂质过氧化对培养人胚肝细胞的损伤作用[J].西安交通大学学报(医学版),1995(1). |
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| 作者姓名： | 和水祥 任瑛云 韩瑽 舒昌杰 谢蔚玫 贺美丽 |
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| 作者单位： | 西安第一临床医学院传染病学教研室 |
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| 摘 要： | 利用四氯化碳造成原代培养人胚肝细胞脂质过氧化损伤模型，发现随培养液中丙二醛含量增加，肝细胞在活率下降，谷丙转氨酶释放增多。同时受损肝细胞白蛋白分泌及胞质膜流动性下降。提示脂质过氧化可引起人胚肝细胞多方面损害。
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| 关 键 词： | 培养细胞 人肝 脂质过氧化 膜流动性 |
INJURIOUS EFFECT OF LIPID PEROXIDATION ON CULTURED HUMAN FETAL HEPATOCYTES |
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| He Shuixiang, Ren Yingyong, Han Cong,et al.INJURIOUS EFFECT OF LIPID PEROXIDATION ON CULTURED HUMAN FETAL HEPATOCYTES[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1995(1). |
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| Authors: | He Shuixiang Ren Yingyong Han Cong |
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| Abstract: | Lipid peroxidation was initiated in cultured human fetal hepatocytes by exposing the cells to carbon tetrachloride (CCl4). The concentration of malondialdehyde(MDA)in medium and the level of ALT release by hepatovytes increased and the cells viability decreased with the increase of CCl4 concentration and exposure time. CCl4 could also decrease the synthesis of albumin and the plasma membrane fluidity. These findings indicate that lipid peroxidation plays a very important role in liver damage. |
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| Keywords: | cultured cells human liver lipid peroxidation membrane fluidity |
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