人白细胞干扰素联合复方水飞蓟蜜丸治疗乙型慢性肝炎的疗效观察

本文报告人白细胞干扰素联合复方水飞蓟蜜丸治疗乙型慢性肝炎15例,采用小剂量(干扰素5万μ/日)长疗程(3～6个月)疗法,乙型肝炎血清标志物在15例中有10例出现有效指标,有效率达66.6%;对照组有效者5例,无效者10例,有效率33.3%,二者相比,有一定差异,但因病例少,差异不显著(P>0.05)。干扰素治疗前后曾检测血中干扰素含量,治疗前血中均测不出,治疗后3～7个月,血中干扰素量可达5～40μ/ml,停药后干扰素含量下降。用药后血中干扰素量明显增高者,疗效好,本文说明抗病毒药联合保肝药治疗乙型肝炎有一定作用,但仍需进一步观察。

EFEECT OF ALPHA-INTERFERON COMBINED WITH SILYBUM MARINANUM COMPOUND IN TREATMENT OF CHRONIC HEPATITIS B

This paper reports the results of 15 cases of chronic hepatitis B treated with alpha-inter -feron (α-IFN) combined with silybum marinanum compound at a small dose (α-IFN 5000 units/day)in a long treatment course(3-6 months). The cure rate was 66.6% in the treatment group and 33.3% in the placebo group. The amount of α-IFN in the serum of the patients was determined before and after treatment, but no α-IFN in the serum was detected before treatment, α-IFN elevated to 5-40 units/ml after treatment for 3-7 months. However, it would drop when the treatment was stopped. The therapeutic effect was remarkable when the amount of α-IFN in the serum was increased. The results indicate that the anti-viral drug(IFN)combined with silyoum marinanum compound may be used to cure chronic hepatitis B.