| THE CLINICAL SIGNIFICANCE OF PERCENT FREE PSA IN DIFFERENTIATING PROSTATE CANCER AND BENIGN PROSTATE HYPERPLASIA |
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| 作者姓名： | 王子明 张鹏 种铁 赵丽华 |
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| 作者单位： | Department of Urology，Department of Urology，Department of Urology，Department of Urology Second Hospital of Xi'an Jiao tong University，Xi'an 710004，China，Second Hospital of Xi'an Jiao tong University，Xi'an 710004，China，Second Hospital of Xi'an Jiao tong University，Xi'an 710004，China，Second Hospital of Xi'an Jiao tong University，Xi'an 710004，China |
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| 摘 要： | rostatecancer (Pca)isoneofthecommonestmalignanttumorsofmaleinEuropeandAmerica .ThemorbidityofPcainourcountryismuchlowerthaninothercountries,butrecentlyitwasincreasedtotwofold1] .Althoughtheprostatespecificantigen(PSA)isthemostusefultumormarkeravailableforthediagnosisofPca ,nevertheless ,lackssufficientsensitivityandspecificity .Peoplenow putforwardtheconceptofpercentfreePSA (fPSA)andhasbe comethenewdirectionofinvestigation .However ,therestillhavesomeproblemunclearatpresent,es peciallyt…
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| 关 键 词： | 前列腺癌 疾病诊断 前列腺肥大 前列腺特定抗体原 PSA血清测量 |
THE CLINICAL SIGNIFICANCE OF PERCENT FREE PSA IN DIFFERENTIATING PROSTATE CANCER AND BENIGN PROSTATE HYPERPLASIA |
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| Wang Ziming,Zhang Peng,Chong Tie,Zhao Lihua.THE CLINICAL SIGNIFICANCE OF PERCENT FREE PSA IN DIFFERENTIATING PROSTATE CANCER AND BENIGN PROSTATE HYPERPLASIA[J].Academic Journal of Xi’an Jiaotong University,2004,16(1):75-77. |
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| Authors: | Wang Ziming Zhang Peng Chong Tie Zhao Lihua |
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| Institution: | Department of Urology, Second Hospital of Xi'an Jiao tong University, Xi'an 710004, China |
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| Abstract: | Objective To evaluate using prostate specific antigen (PSA) and percent free PSA(fPSA) for the diagnosis of prostate cancer(Pca) and benign prostate hyperplasia(BPH). Methods 315 men with BPH and 55 men with Pca were randomly chosen, serum fPSA and total PSA were determined by ELISA and then we compared the sensitivity and specificity of PSA and percent fPSA for the diagnosis of Pca. Results While using PSA and percent fPSA for the diagnosis of prostate cancer, the sensitivity was similar (89.8% vs. 94.5%, P> 0.05), but the specificity was significanty different (52.7% vs. 89.8%, P< 0.005). Conclusions Using percent fPSA might decrease false-positive and avoid 37.1% negative biopsies as compared with PSA, it is very valuable for the diagnosis of Pca. |
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| Keywords: | PSA percent free PSA prostate cancer diagnosis |
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