| 转铁蛋白在糖尿病肾病和原发性慢性肾小球疾病中的临床意义 |
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| 引用本文： | 尹爱萍,董玲,高妍婷.转铁蛋白在糖尿病肾病和原发性慢性肾小球疾病中的临床意义[J].西安交通大学学报(医学版),2005,26(1):61-63. |
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| 作者姓名： | 尹爱萍 董玲 高妍婷 |
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| 作者单位： | 西安交通大学第一医院肾脏内科,陕西,西安,710061 |
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| 摘 要： | 目的 探讨转铁蛋白(TRF)在糖尿病肾病(DN)和原发性慢性肾小球疾病(CGD)中的临床意义。方法 采用速率散射比浊法测定了114例2型糖尿病 (T2DM)患者、108例CGD患者和30例正常人24h尿TRF排泄量(UTf),并进行比较分析。结果 DN早期TRF较白蛋白(ALB)更早出现异常;CGD患者 UTf与尿总蛋白量(UTP)成正相关,且较后者更敏感。结论 UTf在DN早期明显增加,较白蛋白排泄率(UAER)能更敏感地反映糖尿病早期肾脏损害;UTf与UTP呈正相关。联合检测二者应能更灵敏、更精确地反映肾脏病变。
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| 关 键 词： | 转铁蛋白 白蛋白排泄率 糖尿病肾病 原发性慢性肾小球疾病 |
| 文章编号： | 1671-8259(2005)01-0061-03 |
| 修稿时间： | 2004年5月24日 |
The Clinical significance of urine transferrin in the type 2 diabetic nephropathy and primary chronic glomerular disease |
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| Yin Aiping,Dong Ling,Gao Yanting.The Clinical significance of urine transferrin in the type 2 diabetic nephropathy and primary chronic glomerular disease[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2005,26(1):61-63. |
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| Authors: | Yin Aiping Dong Ling Gao Yanting |
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| Abstract: | Objective To investigate the clinical significance of urine transferrin in the type 2 diabetic nephropathy and primary chronic glomerular disease. Methods The level of TRF and UAER in the urine of 114 patients with type 2 diabetes mellitus (T2DM), 108 patients with CGD and 30 healthy patients was measured by rate nephelometry and analyzed. Results Urine TRF significantly increased earlier than ALB at the early stage of DN; Linear correlation was found by correlation analysis between the level of TRF in urine level and the quantity of protein in urine. Conclusion TRF in urine obviously increased at the early stage of DN. It was more sensitive than UAER to reflect the early renal injury of DM. A statistically significant correlation was found between the TRF level and the quantity of protein in the urine. |
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| Keywords: | transferrin UAER DN CGD |
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