| 阿霉素对培养心肌细胞膜流动性的影响及能气朗的保护作用 |
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| 引用本文： | 田刚,刘治全,耿涛.阿霉素对培养心肌细胞膜流动性的影响及能气朗的保护作用[J].西安交通大学学报(医学版),1996(4). |
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| 作者姓名： | 田刚 刘治全 耿涛 |
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| 作者单位： | Department of Cardiology，First Affiliated Hospital |
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| 摘 要： | 应用荧光探剂（ＤＰＨ）标记完整培养心肌细胞膜脂区，用稳态荧光偏振技术观测阿霉素（ＡＤＲ）对心肌细胞膜流动性的影响及能气朗（ＣｏＱ１０）的保护作用。结果表明，培养液中加入ＡＤＲ能使心肌细胞膜流动性明显低于对照组（Ｐ＜０．０５）；ＣｏＱ１０能有效地对抗ＡＤＲ的损伤作用（Ｐ＜０．０５）。提示ＡＤＲ具有损伤心肌细胞膜的作用，ＣｏＱ１０可保护和维持心肌细胞正常功能。
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| 关 键 词： | 阿霉素，心肌细胞，膜流动性，能气朗 |
THE EFFECT OF ADRIAMYCIN ON THE PLASM MEMBRANE FLUIDITY OF CULTURED CARDIAC MYOCYTE AND THE PROTECTIVE EFFECT OF CO-ENZYME Q_(10) |
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| Tian Gang, Liu Zhiquan, Geng Tao.THE EFFECT OF ADRIAMYCIN ON THE PLASM MEMBRANE FLUIDITY OF CULTURED CARDIAC MYOCYTE AND THE PROTECTIVE EFFECT OF CO-ENZYME Q_(10)[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1996(4). |
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| Authors: | Tian Gang Liu Zhiquan Geng Tao |
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| Abstract: | The effect of adriamycin(ADR) on the plasm membrane fluidity of cultured cardiac myocyte of neonatal rats and the protective effect of co-enzyme Q10 was observed with 1,6-dipheny-1,3,5-hexatriene(DPH)as a fluore-scence probe.The results showed that adding ADR to the cultured medium could make the membrane fluidity reduce signmcantly as compared with the control(P<0.05) ; and adding CoQ10 to the medium protected the membrane fluidity from this change effectively (P<0.05). It is suggested that ADR injures the cardiac myocyte cell membrane, and CoQ10 plays a role in keeping the membrane's function normally. |
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| Keywords: | adriamycin cardiac myocyte membrane fluidity Co-enzyme Q_(10) |
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