| 怀牛膝总皂甙(ABS)对大小白鼠抗生育作用的研究 |
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| 引用本文： | 朱和,车锡平. 怀牛膝总皂甙(ABS)对大小白鼠抗生育作用的研究[J]. 西安交通大学学报(医学版), 1987, 0(3) |
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| 作者姓名： | 朱和 车锡平 |
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| 作者单位： | 西安医科大学药学系药理学教研室，西安医科大学药学系药理学教研室 |
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| 摘 要： | 实验观察了怀牛膝总皂甙(ABS)对大、小白鼠的抗生育作用。结果显示,小鼠妊娠的第1～10天,灌胃给ABS具有显著的抗生育作用,此作用呈剂量(125～1000mg/kg)依赖性关系,其ED_(50)为218±48mg/kg)。小鼠妊娠的第1～5天,ABS500mg/kg灌胃给药具有明显的抗着床作用。但对大白鼠,ABS250～500mg/kg灌胃给药无抗生育作用;2g/kg灌胃时也无堕胎作用。
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STUDY ON ANTIFERTILITY EFFECT OF ACHYRANTHES BIDENTATA SAPONINS (ABS) ON RATS AND MICE |
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| Zhu He Che Xiping. STUDY ON ANTIFERTILITY EFFECT OF ACHYRANTHES BIDENTATA SAPONINS (ABS) ON RATS AND MICE[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1987, 0(3) |
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| Authors: | Zhu He Che Xiping |
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| Abstract: | The antifertility effect of ABS on rats and mice was observed. On 1～10 days of pregnancy of mice, administration of ABS by gavage could effectively prevent pregnancy. ABS(125～1000mg/kg) caused a dose-dependent antifertility effect in mice; and the ED_(50) was 218±48 mg/kg(p=0.95). When 500mg/kg ABS was given orally in mice daily 1～5 days after ma- ting, implantation was effectively prevented. However, when 250～500 mg/kg ABS was given in the same way in rats, there was no antifertility action. Moreover, in rats which had received 2 g/kg ABS orally daily 14～19 days after mating, there was no abortifacient action. |
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| Keywords: | anlifertility abortion pregnancy radix achyranthis bidentatae |
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