| ANALYZING HLA HAPLOTYPE OF THE LOCI HLA-A, -B, AND -DRB1 IN MONGOLIA ETHNIC GROUP |
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| 作者姓名： | 张洪波 李生斌 |
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| 作者单位： | [1]The Key Laboratory of National Ministry of Health for Forensic Sciences [2]Department of Forensic Science, Medical College of Xi＇an Jiaotong University, Xi＇an 710061, China |
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| 摘 要： | Objective To investigate HLA-A ,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on 93 individuals by PCR-sequence-based typing （SBT） method. Results Twenty-one alleles were detected for HLA-A, 44 for HLA-B, and 26 for HLA-DRBI. The most frequent alleles were HLA-A ＊ 2402（0. 2097）, HLA-B ＊ 1302（0.0699）, and HLA-DRBI ＊ 0701 （0. 1237）. The most common HLA-A-B-DRBI haplotype were A ＊ 3001-B ＊ 1302-DRB1 ＊ 0701, A ＊ 0101-B ＊ 3701-DRB1 ＊ 1001, followed by the A ＊ 0201-B ＊ 4601-DRB1 ＊ 0901, A ＊ 2402-B＊ 4801-DRB1 ＊ 1101, A＊ 2402-B＊ 5201-DRB1 ＊ 1501, A ＊ 3201-B ＊ 3503-DRB1 ＊ 1301, and A＊ 3303-B ＊ 5801-DRB1 ＊ 0301, which were also presented in Chinese populations. Conclusion The data can be used in forensic and paternity tests to estimate the frequency of a DNA profile or anthropologic research. The characteristics of the distribution of HLA alleles revealed that Mongolia ethnic group is characterized by northern Mongolian Chinese.
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| 关 键 词： | 蒙古人群体 HLA单体型 等位基因频率 不均衡结合 |
| 文章编号： | 1671-8267（2006）02-0142-04 |
ANALYZING HLA HAPLOTYPE OF THE LOCI HLA-A, -B, AND -DRB1 IN MONGOLIA ETHNIC GROUP |
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| Zhang Hongbo,Li Shengbin.ANALYZING HLA HAPLOTYPE OF THE LOCI HLA-A, -B, AND -DRB1 IN MONGOLIA ETHNIC GROUP[J].Academic Journal of Xi’an Jiaotong University,2006,18(2):142-145. |
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| Authors: | Zhang Hongbo Li Shengbin |
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| Abstract: | Objective To investigate HLA-A,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on 93 individuals by PCR- sequence-based typing (SBT) method. Results Twenty-one alleles were detected for HLA-A, 44 for HLA-B, and 26 for HLA-DRB1. The most frequent alleles were HLA-A*2402(0.2097), HLA-B*1302(0.0699), and HLA-DRB1*0701(0.1237). The most common HLA-A-B-DRB1 haplotype were A*3001-B*1302-DRB1*0701, A*0101-B*3701-DRB1*1001, followed by the A*0201-B*4601-DRB1*0901, A*2402-B*4801-DRB1*1101, A*2402-B*5201-DRB1*1501, A*3201-B*3503-DRB1*1301, and A*3303-B*5801-DRB1*0301, which were also presented in Chinese populations. Conclusion The data can be used in forensic and paternity tests to estimate the frequency of a DNA profile or anthropologic research. The characteristics of the distribution of HLA alleles revealed that Mongolia ethnic group is characterized by northern Mongolian Chinese. |
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| Keywords: | Mongolia ethnic group HLA haplotypes allele frequency linkage disequilibrium |
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