| 多药耐药相关蛋白和P-糖蛋白在原发性肾癌中的表达及其临床意义 |
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| 引用本文： | 雷延年,虎威.多药耐药相关蛋白和P-糖蛋白在原发性肾癌中的表达及其临床意义[J].西安交通大学学报(医学版),2001,22(4):351-353. |
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| 作者姓名： | 雷延年 虎威 |
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| 作者单位： | 西安铁路中心医院泌尿外科 |
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| 基金项目： | 郑州铁路局科技处资金资助(№:OOW13(2000)) |
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| 摘 要： | 目的 探讨多药耐药相关蛋白 (MRP)和P 糖蛋白 (P GP)在原发性肾癌中的表达及临床意义。方法 应用免疫组织化学方法对 46例原发性肾癌进行MRP和P GP的检测。结果 MRP及P GP在肾癌的表达率分别为 6 3% (2 8/ 46 )和 85 % (39/ 46 ) ,MRP及P GP的表达与肾癌的组织分级无关。结论 原发性肾癌中MRP及P GP高表达 ,其可能为肾癌内源性耐药的重要机制。
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| 关 键 词： | 肾癌 多药耐药相关蛋白 P糖蛋白 |
| 文章编号： | 0258-0659(2001)04-0351-03 |
| 修稿时间： | 2000年12月15 |
Expression of multidrug resistance-associated protein and P-glucoprotein in hunan renal carcinoma |
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| Lei Yannian,Hu Wei.Expression of multidrug resistance-associated protein and P-glucoprotein in hunan renal carcinoma[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2001,22(4):351-353. |
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| Authors: | Lei Yannian Hu Wei |
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| Institution: | Lei Yannian,Hu WeiDepartment of Urology,Xi'an Railway Central Hospital,Xi'an 710054,China |
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| Abstract: | ObjectiveTo explore the expression of multi dr ug resistanceassociated protein and Pglucoprotein in human renal carcinoma.MethodsSABC immunohistochemisty was performed to detect th e expreesion of multidrug resistanceassociated protein(MRP) and Pglucoprotei n(PGP) in 46 patients with the renal carcinoma.ResultsThe po sitive expression rate of MRP was 63%(28/46) and PGP was 85%(39/46) in renal c arcinoma. Statistical analysis showed that there was no relationship between the expression of MRP and PGP in renal carcinoma and degree of renal tissues.ConclusionMRP and PGP may contribute to the intrinsic drug r esistance,and the detection of MRP and PGP may be useful in selecting chemothe rapeutic drug. |
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| Keywords: | renal cell carcinoma multidrug resistanceassociated protein Pglucoprotein |
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