| P物质和表皮生长因子受体在早期银屑病发病中的作用 |
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| 引用本文： | 王万卷,苏宝山,谭升顺,王俊民.P物质和表皮生长因子受体在早期银屑病发病中的作用[J].西安交通大学学报(医学版),2004,25(2):130-131,146. |
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| 作者姓名： | 王万卷 苏宝山 谭升顺 王俊民 |
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| 作者单位： | 1. 西安交通大学第二医院皮肤科,陕西,西安,710004
2. 西安交通大学第二医院病理科,陕西,西安,710004 |
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| 基金项目： | 西安交通大学行动计划—培植项目资助 (0 82 0 1 7) |
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| 摘 要： | 目的 探讨P物质 (substanceP ,SP)和表皮生长因子受体 (epidermalgrowthfactorreceptor ,EGFR)在银屑病发病早期的作用机制。方法 用放射免疫法检测正常组织和各期银屑病皮损处SP和EGFR的表达状况。结果 进行期银屑病患者和静止期银屑病患者皮损处SP明显高于恢复期患者和正常人 (P <0 .0 5 )。进行期和静止期银屑病患者皮损表皮中EGFR阳性表达明显高于正常皮肤 (P <0 .0 5 ) ;恢复期皮损的阳性表达与正常组织无显著差异性 (P >0 .0 5 )。结论 SP和EGFR可能在银屑病发病的早期阶段相互协同而起关键作用
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| 关 键 词： | P物质 银屑病 表皮生长因子受体 |
| 文章编号： | 1671-8259(2004)02-0130-02 |
Effect of substance P and epidermal growth factor receptor on the pathogenesis of early psoriasis |
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| Wang Wanjuan,Su Baoshan,Tan Shengshun,Wang Junmin.Effect of substance P and epidermal growth factor receptor on the pathogenesis of early psoriasis[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2004,25(2):130-131,146. |
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| Authors: | Wang Wanjuan Su Baoshan Tan Shengshun Wang Junmin |
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| Abstract: | Objective To explore the pathogenesis of substance P (SP) and epidermal growth factor receptor (EGFR) in early psoriasis vulgaris. Methods SP and EGFR were detected in normal skin tissues and psoriatic lesions by radioimmunoassay. Results Expression of SP was significantly enhanced in active and stable psoriasis than in recovery lesions and normal ones (P< 0.05). There was distinctly higher expression of EGFR in active and stable psoriasis than in normal ones (P< 0.05); there was no significant difference between recovery psoriasis and normal ones (P> 0.05). Conclusion SP and EGFR may work together to play a key role in the early pathogenesis of psoriasis. |
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| Keywords: | substance P psoriasis epidermal growth factor receptor(EGFR) |
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