多抗甲素对小鼠S180实体瘤生长的影响及其抑瘤机制的初步分析

多抗甲素是我国首创的甲型链球菌抗癌制剂。动物实验及临床应用证明该药具有抑瘤作用,但对其作用机制不甚明了。本文用小鼠S180实体瘤对多抗甲素抑制肿瘤的机制进行了初步探讨实验结果表明多抗甲素确有抑瘤作用。多抗甲素可激活Mφ,使其呈现典型的活化特征,活化Mφ在体外粘附及杀伤瘤细胞能力增强:用药后瘤周浸润的Mφ数目增多,肿瘤出血坏死更为显著;提示在多抗甲素抑瘤效应中活化的Mφ起着重要作用。实验结果还提示多抗甲素的直接细胞毒性作用及宿主的特异性抗肿瘤免疫在本实验的抑瘤效应中并无实际意义。

A PRELIMINARY STUDY ON THE EFFECT OF POLYACTIN A ON MOUSE SARCOMA 180 AND ITS MECHANISMS OF TUMOR SUPPRESSION

Polyactin A,a substance isolated from al and clinical studies have proved its ability to suppress tumor growth,however,little is known about its mechanisms of action.The purpose of this article is toinvestigate the effect of polyactin A on the growth ofmouse transplanted sarcoma 180 and its mechanisms.Our results showed that Polyactin A couldsingnificantly reduce the growth rate of transplantedsarcoma 180.As compared with control groups,Polyactin A could activate macrophages;most of suchactivated macrophages bound with tumor cells in vitro,and some of the tumor cells showed destructivechanges;at the tumor site,the infiltrating macrophagesof Polyactin A groups increased and tumor necrosisand bleeding were much more serious.These findingssuggest that macrophage activation induced byPolyactin A may play an important role in its suppres-sion of tumor growth.Our results also indicate thatthe direct cytotoxic effect of Polyactin A against tumorcells and the specific anti-tumor immunity of the hostmay have o,if any,effect in this tumor suppressiveprocess