| 扩张性心脏病与备解素因子B遗传多态现象相关性的研究 |
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| 引用本文： | 薛明战,刘治全,袁祖贻,封启明,李学成.扩张性心脏病与备解素因子B遗传多态现象相关性的研究[J].西安交通大学学报(医学版),1997(1). |
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| 作者姓名： | 薛明战 刘治全 袁祖贻 封启明 李学成 |
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| 作者单位： | 西安第一临床医学院心内科!西安710061(薛明战，刘治全，袁祖贻，封启明)，西安妇幼卫生系!西安710061(李学成) |
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| 摘 要： | 利用琼脂糖凝胶高压电泳及免疫固定技术检测了66例扩张性心肌病（DCM）患者的备解素因子B（Bf）的遗传多态性，并与326例健康献血员作了比较。结果发现：DCM组的BfFF表型和Bf*F频率明显升高（x2分别为17．4和16．0，P＜0．001），而BfSS与Bf*S的频率则明显降低（x2分别为3．902和11．491，P＜0．05）；关联分析显示Bf的遗传多态性与DCM的遗传易感性相关联。这一结果提示BfFF和Bf*F可作为DCM的易感性标记之一。
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| 关 键 词： | 扩张性心肌病 遗传学 备解素因子B 遗传多态性 关联研究 |
STUDY OF THE ASSOCIATION BETWEEN BF POLYMORPHISM AND CARDIOMYOPATHY |
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| Xue mingzhan,Liu zhiquan,Yuan zuyi,et al.STUDY OF THE ASSOCIATION BETWEEN BF POLYMORPHISM AND CARDIOMYOPATHY[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1997(1). |
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| Authors: | Xue mingzhan Liu zhiquan Yuan zuyi |
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| Abstract: | Bf polymorphisms were studied using high ovltage agarose gel electrophorosis and immunofixation in 66 patients with dilated cardiomyopathy. Compared with 326 health controls, thefrequencies of BfFF and Bf* F in DCM group wereincreased significantlly (X2: 17.4 and 16. 0, respectively), and the frequencies of BfSS and Bf*S weredecreased significantlly (X2: 3. 9 and 11. 5 ). The association analysis indicated that Bf polymorphismsare associated with DCM. This result suggestedthat Bf polymorphisms could be used as a mark ofsusceptibility for DCM. |
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| Keywords: | dilated cardiomyopath Bf polymorphism association analysis |
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