| THE TREATMENT OF HEPATIC CARCINOMA WITH HERPES SIMPLEX THYMIDINE KINASE GENE／ACYCLOVIR SYSTEM |
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| 引用本文： | 李旭,潘承恩,郭佑民,胡国瑛,陈葳,刘亚民,林蓉,刘青光.THE TREATMENT OF HEPATIC CARCINOMA WITH HERPES SIMPLEX THYMIDINE KINASE GENE／ACYCLOVIR SYSTEM[J].西安交通大学学报(英文版),1996(2). |
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| 作者姓名： | 李旭 潘承恩 郭佑民 胡国瑛 陈葳 刘亚民 林蓉 刘青光 |
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| 作者单位： | Center of Clinical Molecular Biology，First Affiliated Hospital，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | ＴＨＥＴＲＥＡＴＭＥＮＴＯＦＨＥＰＡＴＩＣＣＡＲＣＩＮＯＭＡＷＩＴＨＨＥＲＰＥＳＳＩＭＰＬＥＸＴＨＹＭＩＤＩＮＥＫＩＮＡＳＥＧＥＮＥ／ＡＣＹＣＬＯＶＩＲＳＹＳＴＥＭＬｉＸｕ；，ＰａｎＣｈｅｎｇ＇ｅｎ；；，ＧｕｏＹｏｕｍｉｎ；，ＨｕＧｕｏｙｉｎｇ；Ｃｈ...
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HE TREATMENT OF HEPATIC CARCINOMA WITH HERPES SIMPLEX THYMIDINE KINASE GENE/ACYCLOVIR SYSTEM |
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| Li Xu,Pan Cheng'en,Guo Youmin,Hu Guoying,Chen Wei,Liu Yamin,Lin Rong,Liu Qingguang.HE TREATMENT OF HEPATIC CARCINOMA WITH HERPES SIMPLEX THYMIDINE KINASE GENE/ACYCLOVIR SYSTEM[J].Academic Journal of Xi’an Jiaotong University,1996(2). |
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| Authors: | Li Xu Pan Cheng'en Guo Youmin Hu Guoying Chen Wei Liu Yamin Lin Rong Liu Qingguang |
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| Abstract: | A retroviral vector(LNHcTL)containing the herpes simplex virus type 1 thymldine kinase(HSVI-tk)gene was constructed and used for transduction of the gene into human hepatocellular carcinoma cells(SMMC-7721).Xenografted tumor on nude mice was produced with the injection of the transduced cells(SMMC- 7721/LN HcTL) inoculated subcutaneously and showed regression when treated with Acyclovir.The mean weight of the residual tumors was six times less than that of the controls'tumors. Patients with liver carcinoma were given an intratumoral injection of ampbotropic packing cells(PA317/LNHcTL)producing HSV1-tk recombinant retroviral particles,and then treated with Acyclovir intravenously, which showed a marked regression of the tumor.Our preliminary data suggest that HSV1-tk gene/Acyclovir system might be a useful therapeutic approach for the treatment of hepatic carcinoma in humans. |
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| Keywords: | thymidine kinase retroviral vector Acyclovir gene therapy liver cancer |
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