急性冠状动脉狭窄对局部血液流变学和球结膜微循环的影响

在１３ 条开胸犬上，观察了冠脉不同程度狭窄时血液流变学与球结膜微循环的变化。结果：冠脉轻度狭窄后，乳酸增加，全血粘度及红细胞压积增加，全血粘度在低切变率下增加，在高切变率下仅重度狭窄时增加。球结膜微循环也显示相同的障碍。低切变率下的异常及球结膜微循环的障碍与冠脉狭窄的严重程度相平行。结论：冠脉狭窄达７８％ 以上可引起局部血液流变学异常，这种异常可从球结膜微循环上反映

INFLUENCE OF CORONARY ARTERY STENOSIS ON BLOOD RHEOLOGY AND CONJUNCTIVAL MICROCIRCULATION IN DOGS

In 13 open chest mongel dogs, mild,critical and severe stenosis were produced on left cirumflex coronary artery with a micromiter constrictor.Lactate, blood rheology and conjunctival microcirculation were measured.After coronary artery stenosis, lactate, plasm viscosity, hemotocrit and whole blood viscosity (ηb) at low shear rates were increased, at high shear(192s 1 ) was raised in severs stenosis.An increase in capillary net and RBC aggregative ability ,marked sludging and stenosis with slowed flow were observed.The changes of low shear rates and microcirculation were in concordance with severity of coronary artery stenosis.It can be concluded that coronary artery stenosis (over 78%) leads to abnormality in the blood rheology and the abnormality can be showed in conjunctival microcirculation.So it is helpful to understand the damage of coronary artery disease by observing the change of conjunctival microcirculation.