| dl—四氢巴马汀在子宫平滑肌上的钙拮抗作用 |
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| 引用本文： | 赵东科,赵更生,邱培伦,明祯.dl—四氢巴马汀在子宫平滑肌上的钙拮抗作用[J].西安交通大学学报(医学版),1990(3). |
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| 作者姓名： | 赵东科 赵更生 邱培伦 明祯 |
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| 作者单位： | 西安医科大学药理学教研室
(赵东科，赵更生，邱培伦)，西安医科大学药理学教研室(明祯) |
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| 摘 要： | dl-四氢巴马汀明显对抗催产素和KCl所引起的大鼠离体子宫的收缩反应,对高K~+去极化后Ca~(2+)所引起的子宫收缩有明显松弛作用。使CaCl_2量效曲线右移,并抑制最大效应。对催产素依赖细胞内Ca~(2+)和细胞外Ca~(2+)的两部分收缩均有明显抑制,但对依赖细胞内Ca~(2+)的收缩抑制更强。结果表明dl-四氢巴马汀在子宫平滑肌上具有钙拮抗作用。
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| 关 键 词： | 四氢巴马汀 钙通道阻滞剂 子宫 氯化钾 催产素 |
CALCIUM ANTAGONISTIC EFFECT OF dl-TETRAHYDROPALMATINE ON ISOLATED RAT UTERUS |
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| Zhao Dongke,et al.CALCIUM ANTAGONISTIC EFFECT OF dl-TETRAHYDROPALMATINE ON ISOLATED RAT UTERUS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(3). |
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| Authors: | Zhao Dongke |
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| Institution: | Department of Pharmacology |
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| Abstract: | The calcium antagonistic effect of dl-tetrahydropalmatine(THP) on isolated rat uterus was observed. THP decreased significantly uterine contraction induced by oxytocin, KCl, CaCl_2. THP nonparallelly shifted cacium chloride dose-response curve to the right, and decreased the maximal response, showing noncompetitive antagonism, PD'_2 value was 4.6. THP obviously decreased the intracellular and extracellular calcium-dependent components in oxytocin-induced contraction response. These results have shown that THP not only mainly inhibited potential dependent calcium channel, but also decreased calcium relesese from intracellular stores. |
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| Keywords: | tetrahydropalmatine calcium channel blockers uterus potassium chloride oxytocin |
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