流行性出血热患者血清特异性抗体的动态观察

一、本文检测95例出血热患者487份血清中,出血热IgM及IgG抗体皆为阳性,而非出血热流行地区健康人血清30份及非出血热患者血清30份,皆为阴性。二、出血热患者血清中IgM抗体于病程第1日可检出,3—12日阳性率最高,以后逐渐下降。其滴度2—3病日开始增高,3—6病日达高峰,持续6—12天,第10—14病日逐渐下降。IgG抗体于病程第2日可检出,4—5病日阳性率上升,7—14病日达高峰,其滴度于检出后逐渐增高,5—14病日始达高峰。三、患者病情轻重与血清中抗体水平呈正相关。

Studies on Serum Antibodies Reactant in Hemorrhagic Fever with Renal Syndrome

In this paper 487 specimens of serum antibodies were studied in 95 cases of hemorrhagic fever. In patients with hemorrhagic fever IgM and IgG antibodies were positive, but 30 serum specimens of healthy persons in the non-epidemic arae and 30 patients without the disease were negative. IgM antibodies were abtained on the first day after illness. The positive rate was the highest from the third to the twelveth day after illness, and then it was gradually decreased. The titre began to rise 2—3 days after illness. IgG antibodies were detected out on the second day after onset. The positive rate of serum dilution rose on the fourth or the fifth day and reached the highest peak between 7—14 days. The titre was 1:5120. The conditions were mild or severe proportionally to the level of serum antibodies.