精神分裂症患者不典型抗精神病药治疗前后甲状腺激素的变化

目的探讨不典型抗精神病药对精神分裂症患者甲状腺功能的影响。方法对30例健康对照及63例用利培酮或奥氮平治疗4周的精神分裂症患者,检测治疗前后患者及健康对照的血浆T3、T4、促甲状腺素(TSH)水平。结果精神分裂症患者血浆T3、T4、TSH水平较健康对照组低,T3、T4均有统计学差异(P<0.05)。利培酮治疗后血浆T3水平明显升高,较奥氮平组差异有统计学意义(P<0.05)。治疗前首发精神分裂症患者血浆T3、T4水平均显著低于健康对照组(P<0.05)。结论精神分裂症患者本身可能存在甲状腺功能异常。利培酮治疗有利于改善甲状腺功能。

Changes in thyroid functions of schizophrenic patients before and after treatment with non-typical anti-psychotic drugs

Objective To study the effects of non-typical anti-psychotic drugs on thyroid functions of schizophrenic patients. Methods We recruited 30 healthy controls and 63 schizophrenic patients under the treatment of risperidone or olanzapine for 4 weeks.Their plasma levels of thyroid hormones(T3,T4 and TSH) were measured before and after treatment. Results The levels of plasma T3,T4 and TSH were lower in the schizophrenia group than in the control group,with T3 and T4 levels being significantly different(P<0.05).Plasma T3 level increased significantly after risperidone treatment compared with that after olanzapine treatment(P<0.05).Before anti-psychotic drug treatment,patients with initial onset of schizophrenia had lower plasma T3 and T4 levels than the healthy controls(P<0.01). Conclusion Schizophrenic patients may have abnormal thyroid functions,which could be ameliorated by the treatment with risperidone.