癌胚抗原放射免疫分析的临床应用

本文报告了663例住院病人之血清CEA及36例胸水CEA放射免疫测定结果。476例肺、胃、肠道、肝、食道癌肿之血清CEA阳性率分别为64.29％、47.27％、40.63％、33.33％、31.48％;187例良性病人(食道除外),假阳性率分别为4.76％、11.96％、7.7％、26.47％;36例胸水中有17例肺癌患者,阳性率为94.12％;17例良性病变中无1例假阳性。结果认为测定胸水CEA水平对鉴别肺良、恶性疾病有其独特的临床价值。血清CEA水平不能独立地作为某些肿瘤的诊断依据。但鉴别原发与继发肝癌、肿瘤的术后随访以及对慢性萎缩性胃炎患者进行动态观察尚有一定意义。

CLINICAL APPLICATION OF CARCINOEMBRYONIC ANTIGEN RADIOIMMINOASSAY

The CEA concentrations of 663 serum and 36 pleural fluid samples were determined by radioimminoassay (RIA). The serum CEA positive rates in 476 patients with carcinoma of the lung, gastric,intestinal tract, liver and esophagus were 64.29%, 47.27%, 40.63%, 33.33% and 31.48%, respectively. The false positive rates in 187 patients with benign disease (with the exception of esophagus) were 4.76%, 11.96% and 26.47%, respectively. The pleural fluid CEA positive rate in 17 patients with lung cancer was 94.12%, and none of all 17 patients with lung benign disease were negative. These results suggest that CEARIA of pleural effusion of value in differentiating the lung malignant from benign disease. The CEA concentration of serum alone could not be taken for a diagnostic evidence for some cancers. However, it is significante in recognizing primary and metastic carcinoma of liver, in following up pestoperative tumors and in the dynamic observation of satients with chronic atrophic gastritis.