| 大鼠蓝斑酪氨酸羟化酶免疫反应性神经元的老年性变化 |
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| 引用本文： | 王国明,张可仁,张樟进,马菊芬.大鼠蓝斑酪氨酸羟化酶免疫反应性神经元的老年性变化[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 王国明 张可仁 张樟进 马菊芬 |
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| 作者单位： | 西安医科大学人体解剖学教研室
(王国明，张可仁，张樟进)，西安医科大学人体解剖学教研室(马菊芬) |
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| 摘 要： | 本实验用免疫金银染色法结合图像定量分析,观察了幼年(3个月)、中年(12个月)和老年(20个月)Wistar雄性大鼠蓝斑内酪氨酸羟化酶(TH)免疫反应性神经元的老年性变化,结果:蓝斑内TH免疫反应性神经元数量在中年呈显著性的减少(P<0.01),至老年,进一步减少,与幼年组比较,神经元丧失70%;TH免疲反应性神经元的胞体平均截面积随年龄增长呈增大趋势,各年龄组间有显著性差异(P<0.05);TH免疫反应性神经元的灰度值随增龄而递减,老年组与幼年组相比,下降了39%。表明蓝斑内儿茶酚胺能神经元所含TH的量和活性在衰老过程中是逐渐降低的,提示儿茶酚胺能神经递质合成能力减弱。
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| 关 键 词： | 蓝斑 TH免疫反应性神经元 免疫细胞化学 大鼠 |
AGING CHANGES IN TYROSINE HYDROXYLASE IMMUNOREATIVE NEURONS IN THE LOCUS COERULEUS OF THE RAT |
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| Wang Guoming,Zhang Keren,Zhang Zhangjin,et al.AGING CHANGES IN TYROSINE HYDROXYLASE IMMUNOREATIVE NEURONS IN THE LOCUS COERULEUS OF THE RAT[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Wang Guoming Zhang Keren Zhang Zhangjin |
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| Institution: | Department of Anatomy |
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| Abstract: | Aging changes of tyrosine hydroxylase (TH) -immuno reactive neurons in the locus coeruleus were examined in young (3 month-old). adult(12 month-old) and aged(20 month-old) Wistar male rats, using the IGSS method and image quantitative analysis. The results obtained are as follows: ① The number of TH-immunoreactive neurons docreased markedly (P<0.01)in adult rats and docrcased further in old rats. The number of neurons compared with that in young rots declined by 70% in old rats. ② The area of TH-immunoreactive neuronal somas increased with aging and had significant difference among separate groups (P<0.05). ③ The gray value of TH-immunoreactive neurons declined gradually from the young to the old and decreased by 39% in old rats. The results suggested that TH content and activity contained in neurons of the locus coeruleus declined continually with aging. |
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| Keywords: | locus coeruleus TH-immunoreactive neurons quantitative immunocytochemistry aging changes rat |
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