| ANALYSIS ON GENETIC POLYMORPHISM OF 6 STR LOCI ON CHROMOSOME 12 IN CHINESE HAN POPULATION |
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| 作者姓名： | 左弘 郭雄 康龙丽 平智广 王世捷 张宝弟 赖江华 耿冬 |
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| 作者单位： | The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China，The Key Laboratory of Environment and Genes Related to Diseases，Minutesistry of Education Iinstitue of Environment and Endemic Diseases，Xi'an Jiaotong University，Xi'an 710061，China |
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| 基金项目： | TheworkwassupportedbytheNationalNaturalScienceFundationofChina(No.30371252)andHitechResearchandDevelopmentProgramofChina(863Program)(No.2002BA711A08) |
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| 摘 要： | Shorttandemrepeats(STRs)arearichsource ofhighlypolymorphicmarkersinthehumange nome,arerelativelysmallinsize,andcanbestud iedwiththerelativeexpediently.ThustheSTR polymorphismsarehighlyusefultoolsforlinkagea nalysisofdisease relatedgenesandconstructionthe …
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| 关 键 词： | 遗传多样性 遗传学 STRs 人体遗传 染色体 |
| 文章编号： | 1671-8267（2005）02-0160-04 |
ANALYSIS ON GENETIC POLYMORPHISM OF 6 STR LOCI ON CHROMOSOME 12 IN CHINESE HAN POPULATION |
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| Zuo Hong;Guo Xiong;Kang LongLi;Ping ZhiGuang;Wang ShiJie;Zhang BaoDi;Lai JiangHua;Geng Dong.ANALYSIS ON GENETIC POLYMORPHISM OF 6 STR LOCI ON CHROMOSOME 12 IN CHINESE HAN POPULATION[J].Academic Journal of Xi’an Jiaotong University,2005,17(2):160-163,167. |
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| Authors: | Zuo Hong;Guo Xiong;Kang LongLi;Ping ZhiGuang;Wang ShiJie;Zhang BaoDi;Lai JiangHua;Geng Dong |
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| Abstract: | Objective To analyze the genetic polymorphism of 6 STR loci (D12S358, D12S1675, D12S1663, D12S1697, D12S1725 and D12S1613) on chromosome 12 in Chinese Han population. Methods EDTA-blood specimens were collected from 153 unrelated individuals of Chinese Han population in Shaanxi province. Allele and genotype frequencies for the 6 STR loci were estimated and statistical parameters of polymorphism were calculated. Results 8 alleles and 18 genotypes, 10 alleles and 17 genotypes, 9 alleles and 15 genotypes, 12alleles and 29 genotypes, 12 alleles and 31 genotypes, 8 alleles and 11 genotypes were observed at D12S358, D12S1675, D12S1663, D12S1697, D12S1725 and D12S1613, respectively. No deviations of the observed allele frequency from Hardy-weinberg equilibrium expectations were found for any of these loci. The Heterozygotes of these 6 loci were 78.89%, 66.10%, 54.95%, 79.10%, 71.98% and 59.48%, respectively. It indicated the high genetic polymorphism of the loci in Chinese Han population. Conclusion The 6 STR loci belonged to the genetic marker system of high discriminutesation and high information in Chinese Han population and can be used in the study of gene-related diseases. |
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| Keywords: | short tandem repeat genetic polymorphism Hardy-Weinberg equilibrium chromosome 12 |
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