| EFFECT OF CAPSAICIN ON SUBSTANCE P IN PSORIASIS VULGARIS |
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| 作者姓名： | 王万卷 谭升顺 |
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| 作者单位： | Department of Dermatology，Second Hospital of Xi'an Jiaotong University，Department of Dermatology，Second Hospital of Xi'an Jiaotong University Xi'an 710004，China，Xi'an 710004，China |
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| 摘 要： | Psoriasisischaracterizedbyabnormalker atinocyteprolifertion ,terminaldifferentiationanddermalangiogenesis.Presentevidencesuggeststhatpsoriasiscouldbeinducedandexacerbatedbystress(neuropsychicfactors) .Neuropeptideswhicharelo catedperivascularlyclosetosympatheticandsensorynerveendings,suchassubstanceP(SP)mayplayaroleinthepathogenesisofpsoriasisbyinvolvingindermalinflammatoryresponses1 ] .Somestudiesin dicatedthatcapsaicincouldblocktheconductionofsensorynerveendingviainhibitingthesynthesizeand…
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EFFECT OF CAPSAICIN ON SUBSTANCE P IN PSORIASIS VULGARIS |
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| Wang Wanjuan,Tan Shengshun.EFFECT OF CAPSAICIN ON SUBSTANCE P IN PSORIASIS VULGARIS[J].Academic Journal of Xi’an Jiaotong University,2003,15(2). |
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| Authors: | Wang Wanjuan Tan Shengshun |
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| Institution: | Department of Dermatology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004,China |
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| Abstract: | Objective To the investigate the mechanism of capsaicin in psoriasis vulgaris. Methods Substance P(SP) in psoriatic lesions before and 6 weeks after the treatment with capsaicin was detedted by radioimmunoassary. Results After 3 weeks and 6 weeks treatment with capsaicin, SP in psoriatic lesions was decreased (P<0.05), while it in the self-control group was not decreased; Overall the efficient incidence in therapeutic group was 78.8% , while it in the control group was 36.8%. There was significant difference between them (χ2=16.30, P<0.001). Conclusion Capsaicin inhibits dermal inflammatory responses and proliferation of keratinocytes by decreasing the expression of SP in psoriasis vulgaris. |
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| Keywords: | substance P capsaicin psoriasis vulgaris |
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